Reduction of prefrontal cortex glucose metabolism common to three types of depression.
Reduction of prefrontal cortex glucose metabolism common to three types of depression.
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DOI：
10.1001/archpsyc.1989.01810030049007
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发表时间：
1989-03
影响因子：
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通讯作者：
L. Baxter;Jeffrey M. Schwartz;M. Phelps;J. Mazziotta;B. Guze;C. Selin;R. Gerner;R. Sumida
中科院分区：
文献类型：
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作者：
L. Baxter;Jeffrey M. Schwartz;M. Phelps;J. Mazziotta;B. Guze;C. Selin;R. Gerner;R. Sumida
使用正电子发射断层扫描，我们研究了无药物，年龄和性别匹配，右利手的单相抑郁症（n = 10），双相抑郁症（n = 10），强迫症（OCD）继发性抑郁症（n = 10），强迫症无抑郁症（n = 14）和正常对照组（n = 12）的脑葡萄糖代谢。抑郁症患者在汉密尔顿抑郁评定量表上进行抑郁匹配，患有强迫症而无抑郁症的受试者和患有抑郁症的强迫症患者的强迫症水平相似，而患有抑郁症的强迫症患者的强迫症病理水平相似。我们还研究了6名非性别匹配的躁狂症患者。左背侧前外侧前额叶皮质的平均（+/- SD）葡萄糖代谢率除以同侧半球整体的葡萄糖代谢率（ALPFC/hem），在原发性抑郁症中相似（单相抑郁= 1.05 +/- 0.05;双相抑郁组（1.04 ± 0.05）显著低于正常对照组（1.12 ± 0.06）和强迫症组（1.15 ± 0.05）。右半球的结果相似。强迫症伴抑郁症受试者的数值（1.10 +/- 0.05）也显著低于强迫症不伴抑郁症受试者，双相抑郁症受试者的数值在左半球低于躁狂受试者（1.12 +/- 0.03），尽管结果在右半球不显著。HAM-D评分与左侧ALPFC/hem之间存在显著相关性。抑郁症药物治疗组（n = 12），左侧ALPFC/hem显著增加，汉密尔顿量表评分的百分比变化与左侧ALPFC/hem的百分比变化相关。（250字处删节）
Using positron emission tomography, we studied cerebral glucose metabolism in drug-free, age- and sex-matched, right-handed patients with unipolar depression (n = 10), bipolar depression (n = 10), obsessive-compulsive disorder (OCD) with secondary depression (n = 10), OCD without major depression (n = 14), and normal controls (n = 12). Depressed patients were matched for depression on the Hamilton Depression Rating Scale, and subjects with OCD without depression and OCD with depression had similar levels of OCD without depression and OCD with depression had similar levels of OCD pathology. We also studied six non-sex-matched patients with mania. Mean (+/- SD) glucose metabolic rates for the left dorsal anterolateral prefrontal cortex, divided by the rate for the ipsilateral hemisphere as a whole (ALPFC/hem), were similar in the primary depressions (unipolar depression = 1.05 +/- 0.05; bipolar depression = 1.04 +/- 0.05), and were significantly lower than those in normal controls (1.12 +/- 0.06) or OCD without depression (1.15 +/- 0.05). Results for the right hemisphere were similar. Values in subjects with OCD with depression (1.10 +/- 0.05) were also significantly lower than in subjects with OCD without depression, and values in subjects with bipolar depression were lower than those in manic subjects (1.12 +/- 0.03) on this measure in the left hemisphere, although results were not significant in the right hemisphere. There was a significant correlation between the HAM-D score and the left ALPFC/hem. With medication for depression (n = 12), the left ALPFC/hem increased significantly and the percentage change in the Hamilton scale score correlated with the percentage change in the left ALPFC/hem.(ABSTRACT TRUNCATED AT 250 WORDS)