Porphyromonas gingivalis short fimbriae are regulated by a FimS/FimR two-component system.
Porphyromonas gingivalis short fimbriae are regulated by a FimS/FimR two-component system.
复制标题
牙龈卟啉单胞菌短纤维膜受FIMS/FIMR两组分组的调节。
DOI：
10.1111/j.1574-6968.2007.00722.x
复制
发表时间：
2007-06
影响因子：
2.1
通讯作者：
Xie, Hua
中科院分区：
文献类型：
--
作者：
Wu, Jie;Lin, Xinghua;Xie, Hua
Porphyromonas gingivalis possesses two distinct fimbriae. The long (FimA) fimbriae have been extensively studied. Expression of the fimA gene is tightly controlled by a two-component system (FimS/FimR) through a cascade regulation. The short (Mfa1) fimbriae are less understood. The authors have recently demonstrated that both fimbriae are required for formation of P. gingivalis biofilms. Here, the novel finding that FimR, a member of the two-component regulatory system, is a transcriptional activator of the mfa1 gene is promoted. Unlike the regulatory mechanism of FimA by FimR, this regulation of the mfa1 gene is accomplished by FimR directly binding to the promoter region of mfa1.
