Altered thalamocortical and intra-thalamic functional connectivity during light sleep compared with wake
Altered thalamocortical and intra-thalamic functional connectivity during light sleep compared with wake
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DOI：
10.1016/j.neuroimage.2015.10.041
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发表时间：
2016-01-15
期刊：
影响因子：
5.7
通讯作者：
Bagshaw, Andrew P.
中科院分区：
文献类型：
--
作者：
Hale, Joanne R.;White, Thomas P.;Bagshaw, Andrew P.
从清醒到睡眠的转变伴随着大脑丘脑皮质网络活动的改变。与睡眠相关的丘脑皮质功能连接性(FC)下降已有报道，但这些变化在丘脑皮质通路之间的差异程度以及睡眠期间丘脑内FC的模式仍未得到测试。为了非侵入性地研究丘脑皮质和丘脑内Fc随睡眠阶段的变化，我们记录了13名健康受试者进入浅睡眠期间的同步EEG-fMRI数据。脑电数据的视觉评分允许睡眠分期。我们通过计算基于种子的FC，在丘脑体素和一组预定义的皮质区域之间测量，得出了清醒时丘脑的功能性部分。睡眠对这些不同的丘脑亚区和它们相关的皮质投射之间的FC有不同的影响，睡眠期间FC显著增加，仅限于感觉运动连接。相比之下，丘脑内的FC，无论是在丘脑功能分区内还是在丘脑功能分区之间，都显示出随着进入睡眠的推进而显著增加。这项工作展示了丘脑在睡眠/清醒周期中与皮质和内部的功能性关系的复杂性和状态特异性，并进一步强调了丘脑皮质在睡眠机制研究中的重要性。(C)2015 Elsevier Inc.保留所有权利。
The transition from wakefulness into sleep is accompanied by modified activity in the brain's thalamocortical network. Sleep-related decreases in thalamocortical functional connectivity (FC) have previously been reported, but the extent to which these changes differ between thalamocortical pathways, and patterns of intra-thalamic FC during sleep remain untested. To non-invasively investigate thalamocortical and intra-thalamic FC as a function of sleep stage we recorded simultaneous EEG-fMRI data in 13 healthy participants during their descent into light sleep. Visual scoring of EEG data permitted sleep staging. We derived a functional thalamic parcellation during wakefulness by computing seed-based FC, measured between thalamic voxels and a set of pre-defined cortical regions. Sleep differentially affected FC between these distinct thalamic subdivisions and their associated cortical projections, with significant increases in FC during sleep restricted to sensorimotor connections. In contrast, intra-thalamic FC, both within and between functional thalamic subdivisions, showed significant increases with advancement into sleep. This work demonstrates the complexity and state-specific nature of functional thalamic relationships - both with the cortex and internally - over the sleep/wake cycle, and further highlights the importance of a thalamocortical focus in the study of sleep mechanisms. (C) 2015 Elsevier Inc. All rights reserved.