On relationship inference using gamete identity by descent data.
On relationship inference using gamete identity by descent data.
复制标题
通过血统数据使用配子身份进行关系推断。
DOI：
10.1089/106652701300312940
复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Liang,F
中科院分区：
文献类型：
--
作者：
Zhao,H;Liang,F
Related individuals are identical by descent (IBD) at a genetic locus if they share the same DNA material from a common ancestor. Continuous gamete IBD data consist of the lengths of (in order) IBD and non-IBD regions along the genomes for gametes segregating from two related individuals and can be used to distinguish different relationships. Under the assumption that the crossovers follow a Poisson process, we show that the exact calculation of the likelihood of a particular relationship for a given gamete IBD datum is tractable. Greatgrandparent–greatgrandchild and cousin relationships are used as examples to illustrate our methods.
