Human renal response to furosemide: Simultaneous oxygenation and perfusion measurements in cortex and medulla
Human renal response to furosemide: Simultaneous oxygenation and perfusion measurements in cortex and medulla
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DOI：
10.1111/apha.13292
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发表时间：
2019-09-01
影响因子：
6.3
通讯作者：
Andersen, Ulrik B.
中科院分区：
文献类型：
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作者：
Haddock, Bryan;Larsson, Henrik B. W.;Andersen, Ulrik B.
目的肾髓质灌注和代谢紊乱与肾病和高血压的发病有关。速尿是一种循环利尿剂，被广泛用于通过解偶联钠代谢来预防急性肾病肾髓质缺氧，但其对人体髓质灌注的影响尚不清楚。我们使用磁共振成像（MRI）定量成像肾灌注和氧合在速尿之前和期间。根据文献，我们假设速尿会增加髓质氧合，减少髓质灌注，但引起轻微变化(
Aim Disturbances of renal medullary perfusion and metabolism have been implicated in the pathogenesis of kidney disease and hypertension. Furosemide, a loop diuretic, is widely used to prevent renal medullary hypoxia in acute kidney disease by uncoupling sodium metabolism, but its effects on medullary perfusion in humans are unknown. We performed quantitative imaging of both renal perfusion and oxygenation using Magnetic Resonance Imaging (MRI) before and during furosemide. Based on the literature, we hypothesized that furosemide would increase medullary oxygenation, decrease medullary perfusion, but cause minor changes (