Blinded case-control study of the relationship between human coronavirus NL63 and Kawasaki syndrome
Blinded case-control study of the relationship between human coronavirus NL63 and Kawasaki syndrome
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DOI：
10.1086/509509
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发表时间：
2006-12-15
影响因子：
6.4
通讯作者：
Holmes, Kathryn V.
中科院分区：
文献类型：
--
作者：
Dominguez, Samuel R.;Anderson, Marsha S.;Holmes, Kathryn V.
我们在科罗拉多丹佛儿童医院住院的儿科患者中进行了一项盲法、病例对照、回顾性研究，以确定人类冠状病毒（HCoV）-NL 63感染是否与川崎综合征（KS）相关。在7个月的时间内，鼻咽冲洗样本从2（7.7%）的26个连续的儿童KS和4（7.7%）的52个匹配的对照受试者检测HCoV-NL 63的逆转录聚合酶链反应阳性。这些数据表明，尽管在研究期间，HCoV-NL 63在我们社区的儿童中传播，但KS患者中HCoV-NL 63感染的患病率并不比对照受试者高。
We conducted a blinded, case-control, retrospective study in pediatric patients hospitalized at The Children's Hospital, Denver, Colorado, to determine whether human coronavirus (HCoV)-NL63 infection is associated with Kawasaki syndrome (KS). Over the course of a 7-month period, nasopharyngeal-wash samples from 2 (7.7%) of 26 consecutive children with KS and 4 (7.7%) of 52 matched control subjects tested positive for HCoV-NL63 by reverse transcription-polymerase chain reaction. These data suggest that, although HCoV-NL63 was circulating in children in our community during the time of the study, the prevalence of infection with HCoV-NL63 was not greater in patients with KS than in control subjects.