G6PD Viangchan (871G>A) is the most common G6PD-deficient variant in the Cambodian population
G6PD Viangchan (871G>A) is the most common G6PD-deficient variant in the Cambodian population
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DOI：
10.1007/s10038-005-0276-2
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发表时间：
2005-09-01
影响因子：
3.5
通讯作者：
Nuchprayoon, I
中科院分区：
文献类型：
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作者：
Louicharoen, C;Nuchprayoon, I
葡萄糖-6-磷酸脱氢酶(G6PD)缺乏症是东南亚人最常见的遗传性酶病。我们对Chanthaburi省的108名柬埔寨外来劳工和Buriram医院107名柬埔寨新生儿的脐带血样本进行了G6PD突变研究。119名柬埔寨男性中31名(26.1%)和96名女性中3名(3.1%)G6PD缺乏，并接受了G6PD突变检测。在大多数缺乏G6PD的柬埔寨人(28/34；82.4%)中发现G6PD Viangchan(871G&>A)，G6PD Union(1360C&>T)和G6PD Coimbra(592C&>T)各有1例。我们得出结论：G6PD Viangchan(871G>；A)是柬埔寨人中最常见的突变。这一发现与缺乏G6PD的泰国人和老挝人相似，表明这三个国家的人有共同的祖先。
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common hereditary enzymopathy among Southeast Asians. We studied G6PD mutations in 108 migrant Cambodian laborers in Chanthaburi province and cord blood samples from 107 Cambodian newborns at Buriram Hospital. Thirty-one (26.1%) of 119 Cambodian males and three of 96 (3.1%) females were G6PD deficient and were assayed for G6PD mutations. G6PD Viangchan (871G > A) was identified in most G6PD-deficient Cambodians (28 of 34; 82.4%); G6PD Union (1360C > T) and G6PD Coimbra (592C > T) was found in one case each. We concluded that G6PD Viangchan (871G > A) was the most common mutation among Cambodians. This finding is similar to G6PD-deficient Thais and Laotians, suggesting a common ancestry of people from these three countries.