Experimental otitis media evaluated by magnetic resonance imaging: an in vivo model.
Experimental otitis media evaluated by magnetic resonance imaging: an in vivo model.
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通过磁共振成像评估实验性中耳炎：体内模型。
DOI：
10.1177/000348949210100308
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Wolf,GL
中科院分区：
文献类型：
--
作者：
Chan,KH;Swarts,JD;Hashida,Y;Doyle,WJ;Kardatzke,D;Wolf,GL
我们实验室正在探索磁共振成像在中耳炎研究中的应用。在这项研究中，我们提出了一种新的方法来研究由于在灰鼠模型中诱发中耳炎发作而引起的中耳裂的变化。它使用钆-二乙烯三胺五乙酸，一种磁共振成像造影剂，检查炎症发作期间中耳粘膜的吸收和洗脱特征。参数，如时间的最大强度的粘膜和冲洗率的造影剂从粘膜显着相关的感染的持续时间。
The use of magnetic resonance imaging in otitis media research is being explored in our laboratory. In this study, we present a new method for studying changes in the middle ear cleft due to an episode of induced otitis media in the chinchilla model. It uses gadolinium-diethylenetriamine pentaacetic acid, a magnetic resonance imaging contrast agent, to examine the uptake and washout characteristics of middle ear mucosa during an inflammatory episode. Parameters such as the time to maximum intensity of the mucosa and the washout rate of the contrast agent from the mucosa were significantly correlated to the duration of the infection.