A comparison of global coagulation assays between normal controls and patients with thrombocytopenia
A comparison of global coagulation assays between normal controls and patients with thrombocytopenia
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DOI：
10.1111/ijlh.12941
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发表时间：
2019-04-01
影响因子：
3
通讯作者：
Ho, Prahlad
中科院分区：
文献类型：
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作者：
Lim, Hui Yin;Leung, Patrick;Ho, Prahlad
前言一些血小板减少的患者可能有出血的风险，尽管定量的血小板计数并不总是一个足够的预测因素。血栓弹性图(TEG((R)、校准自动血栓图(CAT)和总止血潜力(OHP)等凝血分析方法可以更好地评估个体的止血情况。TAG((R))用于柠檬化全血，CAT和OHP用于缺乏血小板的血浆。结果58例受试者(免疫性血小板减少症24例，化疗/恶性肿瘤相关34例)，平均年龄57.5岁。与正常对照组相比，血小板减少组的最大幅度相似，但血栓溶解能力降低(0.0%比0.6%；P
IntroductionSome patients with thrombocytopenia may be at risk of bleeding although quantitative platelet count is not always a sufficient predictive factor. Global coagulation assays such as thromboelastography (TEG((R))), calibrated automated thrombogram (CAT) and overall haemostatic potential (OHP) may provide a better assessment of an individual's haemostatic profile.MethodsBlood samples were collected from thrombocytopenic patients. TEG((R)) was performed on citrated whole blood, while CAT and OHP were performed on platelet-poor plasma. Results were compared to our previously collected normal controls.ResultsFifty-eight participants (24 immune thrombocytopenia, 34 chemotherapy/malignancy-related) with mean age of 57.5years were recruited. Compared to normal controls, thrombocytopenic participants had comparable maximum amplitude but reduced clot lysis (0.0% vs 0.6%; P