Is CdtB a nuclease or a phosphatase?

Is CdtB a nuclease or a phosphatase?
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CdtB 是核酸酶还是磷酸酶?

DOI:
10.1126/science.291.5504.547a
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发表时间:
2001
期刊:
影响因子:
56.9
通讯作者:
Mensur Dlakić
Mensur Dlakić
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Mensur Dlakić

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Lara-Tejero和Galan([1][1])报道了细胞致死性膨胀毒素B(CDtB)的脱氧核糖核酸酶(DNase)I样活性,导致细胞周期的G2/M过渡期停滞([2][2])。尽管作者指出,在体外,CdtB是一个很差的核酸酶,但他们提出,CdtB-
Lara-Tejero and Galan ([1][1]) reported deoxyribonuclease (DNase) I–like activity of cytolethal distending toxin B (CdtB), which causes arrest in the G2/M transition phase of the cell cycle ([2][2]). Even though the authors noted that CdtB is a poor nuclease in vitro, they proposed that CdtB-