Hematoporphyrin phototherapy for experimental intraocular malignant melanoma.
Hematoporphyrin phototherapy for experimental intraocular malignant melanoma.
复制标题
血卟啉光疗治疗实验性眼内恶性黑色素瘤。
DOI：
10.1001/archopht.1983.01040010901009
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发表时间：
1983
影响因子：
--
通讯作者：
C. Ni
中科院分区：
文献类型：
--
作者：
L. H. Liu;C. Ni
给予血卟啉衍生物（HpD），然后用红光进行光辐射，完全或部分破坏了兔眼前房中出现的格林仓鼠黑色素瘤。将携带肿瘤的眼睛分为两组。 22 只眼睛接受了 HpD 注射，然后暴露于带有 500 W 石英卤素灯和红色滤光片的幻灯片投影仪发出的红光（肿瘤强度约为 4.0 mW/sq cm）。在对照组（六只眼睛）中，眼睛仅暴露于红光或仅接受 HpD 注射。治疗后的局部并发症包括结膜水肿和充血、角膜混浊和虹膜表面出血。 HpD本身没有细胞毒性作用，优先保留在肿瘤细胞中，并由于在肿瘤中产生细胞毒性单线态氧而引起破坏性光动力效应。因此，它可能是治疗葡萄膜黑色素瘤的安全且潜在的治疗方法。
Administration of a hematoporphyrin derivative (HpD) followed by photoradiation with red light completely or partially destroyed Greene hamster melanoma developed in the anterior chamber of rabbit eyes. Tumor-bearing eyes were divided into two groups. Twenty-two eyes received an HpD injection followed by exposure to red light from a slide projector with a 500-W quartz halogen lamp and a red filter (intensity to the tumor was about 4.0 mW/sq cm). In the control group (six eyes), eyes were exposed either to red light only or to HpD injection only. Local complications after therapy included edema and congestion of the conjunctiva, clouding of the cornea, and hemorrhage on the iris surface. The HpD itself has no cytotoxic effect, is preferentially retained in tumor cells, and causes a destructive photodynamic effect as a result of the production of cytotoxic singlet oxygen in the tumor. Accordingly, it may be a safe and potentially therapeutic procedure in the treatment of uveal melanoma.