Administration of an insulin powder to the lungs of cynomolgus monkeys using a Penn Century insufflator
Administration of an insulin powder to the lungs of cynomolgus monkeys using a Penn Century insufflator
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DOI：
10.1016/j.ijpharm.2003.09.038
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发表时间：
2004-01-28
影响因子：
5.8
通讯作者：
Hardy, JG
中科院分区：
文献类型：
--
作者：
Grainger, CI;Alcock, R;Hardy, JG
正在开发一种用于肺部注射的麻疹减毒活疫苗粉末制剂。该粉末的安全性和有效性将通过向食蟹猴吹入来评估。已经对 Penn Century 吹药器对猴子进行粉末给药的情况进行了评估，其中使用的胰岛素制剂具有与疫苗粉末相似的物理化学特性。通过粉末吹入、溶液滴入气管和皮下注射给药后比较胰岛素药代动力学。注射到肺部和气管的胰岛素比皮下注射的胰岛素吸收更快。吸入粉末的胰岛素生物利用度高于滴注溶液的胰岛素生物利用度。研究结果证实，宾夕法尼亚世纪设备适合将疫苗粉末注射到肺部深处。 (C) 2003 Elsevier B.V. 保留所有权利。
A powder formulation of live-attenuated measles vaccine is being developed for administration to the lungs. The safety and efficacy of the powder will be assessed by insufflation into cynomolgus monkeys. A Penn Century insufflator has been evaluated for powder dosing to the monkeys using an insulin formulation having similar physicochemical characteristics to the vaccine powder. Insulin pharmacokinetics were compared following dosing by powder insufflation, solution instillation into the trachea and subcutaneous injection. The insulin dosed to the lungs and trachea was more rapidly absorbed than that administered subcutaneously. Insulin bioavailability was greater from the inhaled powder than from the instilled solution. The findings confirm that the Penn Century device is suitable for vaccine powder dosing to the deep lung. (C) 2003 Elsevier B.V. All rights reserved.