Medicinal Natural Products: A Biosynthetic Approach
Medicinal Natural Products: A Biosynthetic Approach
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DOI：
10.2307/4114524
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发表时间：
1997
影响因子：
4.6
通讯作者：
P. Dewick
中科院分区：
文献类型：
--
作者：
P. Dewick
1.关于这本书，以及如何使用它。主题。目标就是。这种方法。《话题》。这些数字。进一步阅读。要学什么。要学什么。命名法。关于酸、碱和离子的约定。一些常见的缩略语。进一步阅读。2.次生代谢：构建的构件和构建机制。初级和次级代谢。积木。建设机制。烷基化反应：亲核取代。脱氢酶。氧化物酶。单加氧酶。双加氧酶。胺氧化酶。Baeyer-Villiger单加氧酶。一些与构造机制有关的维生素。阐明生物合成途径。进一步阅读。3.醋酸酯途径：脂肪酸和多酮。脂肪酸合成酶：饱和脂肪酸。不饱和脂肪酸。非同寻常的脂肪酸。前列腺素。血栓烷。白三烯。聚酮合成酶：概论。聚酮合成酶：大环内酯类。大环内酯类抗生素，红霉素，奥兰霉素和螺旋霉素，泰乐菌素，阿维菌素，多烯类抗真菌药，他克莫司和西罗莫司，利福霉素。聚酮合成酶：线性聚酮和聚醚。Diels-Alder自行车运动。聚酮合成酶：芳香族。番泻叶，金丝桃/圣约翰？S麦汁，霉酚酸，凯林和色甘酸，灰黄霉素。毒常春藤和毒橡树，大麻，黄曲霉毒素，四环素，蒽环类抗生素。进一步阅读。4.莽草酸途径：芳香氨基酸和苯丙烷类化合物。芳香氨基酸和简单苯甲酸。苯丙烷类化合物。肉桂酸和肉桂酸酯。木脂素和木质素。苯基丙烯。从C6C3化合物中提取的苯甲酸。香豆素。芳香族聚酮。苯丙酮、二芳基庚烷。黄酮类和二苯乙烯类化合物。黄酮木脂素。异黄酮类化合物。萜类喹酮类化合物。进一步阅读。5.甲羟戊酸和甲氧基叔丁醇的磷酸化途径：萜类和类固醇。甲氧丙酮酸和甲基赤藓糖醇磷酸。半萜类化合物。单萜类化合物。不规则单萜。环烯丙烷。倍半萜类化合物。青蒿素、棉酚、毛霉烯。二萜类化合物。七萜类化合物。三萜类化合物。类固醇。立体化学和命名法。胆固醇。植物类固醇。维生素D。类固醇皂苷。心脏活性糖苷。胆汁酸。肾上腺皮质激素/皮质类固醇。皮质类固醇的半合成。促孕素。雌激素。雄激素。四萜类化合物。高级萜类化合物。进一步阅读。6.生物碱。从鸟氨酸中提取的生物碱。由赖氨酸衍生的生物碱。来源于烟酸的生物碱。来源于酪氨酸的生物碱。苯乙胺和简单的四氢异喹啉生物碱。修饰的苯基四氢异喹啉生物碱。苯乙基异喹啉生物碱。萜类四氢异喹啉生物碱。石蒜科生物碱。从色氨酸中提取的生物碱。简单的吲哚生物碱。简单-卡波林生物碱。萜类吲哚生物碱。喹啉生物碱。吡咯吲哚生物碱。麦角生物碱。来源于邻氨基苯甲酸的生物碱。从组氨酸中提取的生物碱。通过胺化反应得到的生物碱。醋酸酯衍生生物碱。苯丙氨酸衍生生物碱。萜类生物碱。类固醇生物碱。嘌呤生物碱。进一步阅读。7.肽、蛋白质和其他氨基酸衍生物。多肽和蛋白质。核糖体多肽的生物合成。多肽激素。甲状腺激素。下丘脑荷尔蒙。激素，生长激素释放激素/因子，生长抑素。脑垂体前叶荷尔蒙。脑垂体后叶激素。胰腺激素。干扰素。阿片肽。核糖体多肽毒素。死亡帽(鹅膏菌)，蓖麻毒素，肉毒杆菌毒素，芋螺毒素，蛇毒，吉拉怪物毒素。酵素。非核糖体多肽的生物合成。杆菌素、卷曲霉素、多粘菌素、达托霉素、环孢素、万古霉素和替考拉宁、博莱霉素、链球菌、放线菌素、环丝氨酸。修饰的多肽：青霉素、头孢菌素和其他？-内酰胺类。生氰苷。硫代葡萄糖苷。半胱氨酸亚硫醚。进一步阅读。8.碳水化合物。单糖。低聚糖。多糖类。氨基糖和氨基糖苷。氨基糖苷类抗生素、含链霉胺的抗生素、含2-脱氧链胺的抗生素、阿卡波糖、林可霉素和克林霉素。进一步阅读。索引。
1. ABOUT THIS BOOK, AND HOW TO USE IT. The Subject. The Aim. The Approach. The Topics. The Figures. Further Reading. What to Study. What to Learn. Nomenclature. Conventions Regarding Acids, Bases, and Ions. Some Common Abbreviations. Further Reading. 2. SECONDARY METABOLISM: THE BUILDING BLOCKS AND CONSTRUCTION MECHANISMS. Primary and Secondary Metabolism. The Building Blocks. The Construction Mechanisms. Alkylation Reactions: Nucleophilic Substitution. Dehydrogenases. Oxidases. Monooxygenases. Dioxygenases. Amine Oxidases. Baeyer-Villiger Monooxygenases. Some Vitamins Associated with the Construction Mechanisms. Elucidating Biosynthetic Pathways. Further Reading. 3. THE ACETATE PATHWAY: FATTY ACIDS AND POLYKETIDES. Fatty Acid Synthase: Saturated Fatty Acids. Unsaturated Fatty Acids. Uncommon Fatty Acids. Prostaglandins. Thromboxanes. Leukotrienes. Polyketide Synthases: Generalities. Polyketide Synthases: Macrolides. Macrolide Antibiotics, Erythromycins, Oleandomycin and Spiramycin, Tylosin, Avermectins, Polyene Antifungals, Tacrolimus and Sirolimus, Rifamycins. Polyketide Synthases: Linear Polyketides and Polyethers. Diels-Alder Cyclizations. Polyketide Synthases: Aromatics. Senna, Hypericum / St John?s Wort, Mycophenolic acid, Khellin and Cromoglicate, Griseofulvin. Poison Ivy and Poison Oak, Cannabis, Aflatoxins, Tetracyclines, Anthracycline Antibiotics. Further Reading. 4. THE SHIKIMATE PATHWAY: AROMATIC AMINO ACIDS AND PHENYLPROPANOIDS. Aromatic Amino Acids and Simple Benzoic Acids. Phenylpropanoids. Cinnamic Acids and Esters. Lignans and Lignin. Phenylpropenes. Benzoic Acids from C6C3 Compounds. Coumarins. Aromatic Polyketides. Styrylpyrones, Diarylheptanoids. Flavonoids and Stilbenes. Flavonolignans. Isoflavonoids. Terpenoid Quinones. Further Reading. 5. THE MEVALONATE AND METHYLERYTHRITOL PHOSPHATE PATHWAYS: TERPENOIDS AND STEROIDS. Mevalonic Acid and Methylerythritol Phosphate. Hemiterpenes. Monoterpenes. Irregular Monoterpenes. Iridoids. Sesquiterpenes. Artemisinin, Gossypol, Trichothecenes. Diterpenes. Sesterterpenes. Triterpenes. Steroids. Stereochemistry and Nomenclature. Cholesterol. Phytosterols. Vitamin D. Steroidal Saponins. Cardioactive Glycosides. Bile Acids. Adrenocortical Hormones/Corticosteroids. Semi-Synthesis of Corticosteroids. Progestogens. Oestrogens. Androgens. Tetraterpenes. Higher Terpenoids. Further Reading. 6. ALKALOIDS. Alkaloids Derived from Ornithine. Alkaloids Derived from Lysine. Alkaloids Derived from Nicotinic Acid. Alkaloids Derived from Tyrosine. Phenylethylamines and Simple Tetrahydroisoquinoline Alkaloids. Modified Benzyltetrahydroisoquinoline Alkaloids. Phenethylisoquinoline Alkaloids. Terpenoid Tetrahydroisoquinoline Alkaloids. Amaryllidaceae Alkaloids. Alkaloids Derived from Tryptophan. Simple Indole Alkaloids. Simple - Carboline Alkaloids. Terpenoid Indole Alkaloids. Quinoline Alkaloids. Pyrroloindole Alkaloids. Ergot Alkaloids. Alkaloids Derived from Anthranilic Acid. Alkaloids Derived From Histidine. Alkaloids Derived by Amination Reactions. Acetate-Derived Alkaloids. Phenylalanine-Derived Alkaloids. Terpenoid Alkaloids. Steroidal Alkaloids. Purine Alkaloids. Further Reading. 7. PEPTIDES, PROTEINS, AND OTHER AMINO ACID DERIVATIVES. Peptides and Proteins. Ribosomal Peptide Biosynthesis. Peptide Hormones. Thyroid Hormones. Hypothalamic Hormones. Hormone, Growth Hormone-releasing Hormone/Factor, Somatostatin. Anterior Pituitory Hormones. Posterior Pituitory Hormones. Pancreatic Hormones. Interferons. Opioid Peptides. Ribosomal Peptide Toxins. Death Cap (Amanita phalloides), Ricin, Botulinum Toxin, Conotoxins, Snake Venoms, Gila Monster Venom. Enzymes. Nonribosomal Peptide Biosynthesis. Bacitracins, Capreomycin, Polymyxins, Daptomycin, Cyclosporins, Vancomycin and Teicoplanin, Bleomycin, Streptogramins, Dactinomycin, Cycloserine. Modified Peptides: Penicillins, Cephalosporins and Other ?-Lactams. Cyanogenic Glycosides. Glucosinolates. Cysteine Sulphoxides. Further Reading. 8. CARBOHYDRATES. Monosaccharides. Oligosaccharides. Polysaccharides. Aminosugars and Aminoglycosides. Aminoglycoside Antibiotics, Streptamine-containing Antibiotics, 2-Deoxystreptamine-containing Antibiotics, Acarbose, Lincomycin and Clindamycin. Further Reading. Index.