Immunocytologic localization of herpes simplex type 1 viral antigens in herpetic retinitis and encephalitis in an adult.
Immunocytologic localization of herpes simplex type 1 viral antigens in herpetic retinitis and encephalitis in an adult.
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DOI：
10.1016/s0161-6420(85)34077-0
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发表时间：
1985
期刊：
影响因子：
13.7
通讯作者：
J. Pepose;A. Kreiger;U. Tomiyasu;P. Cancilla;R. Foos
中科院分区：
文献类型：
--
作者：
J. Pepose;A. Kreiger;U. Tomiyasu;P. Cancilla;R. Foos
应用免疫过氧化物酶技术鉴定视网膜、视神经和大脑中单纯疱疹I型病毒抗原。病毒抗原在视网膜各层、视网膜色素上皮和脉络膜中均可见，在较小程度上可见。右侧视神经的少突胶质细胞以及左侧额叶、下顶叶和颞叶灰质和白质中的神经元和胶质细胞也表达单纯疱疹抗原。灵敏的免疫过氧化物酶方法允许在许多没有核内包涵体或周围炎症的细胞中检测病毒抗原，从而增加了关于疱疹感染的解剖和细胞定位的有价值的信息。成人单纯性疱疹视网膜炎的临床病理特征与巨细胞病毒视网膜病变比较。
An immunoperoxidase technique was utilized to identify herpes simplex type I viral antigens in the retina, optic nerve and brain of an adult with herpetic retinitis and encephalitis. Viral antigens were demonstrated in all layers of retina, retinal pigment epithelium and, to a lesser extent, in choroid. Oligodendroglia in the right optic nerve and neuronal and glial cells in the grey and white matter of the left frontal, inferior parietal and temporal lobes of the brain also expressed herpes simplex antigens. The sensitive immunoperoxidase method allowed detection of viral antigens in many cells without intranuclear inclusions or surrounding inflammation, and thereby added valuable information regarding the anatomic and cellular localization of herpetic infection. The clinicopathologic features that characterize herpes simplex retinitis in the adult are compared to cytomegalovirus retinopathy.