A long-term follow-up of cognitive, emotional, and behavioural sequelae to Reye syndrome
A long-term follow-up of cognitive, emotional, and behavioural sequelae to Reye syndrome
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DOI：
10.1017/s0012162299001164
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发表时间：
1999-08-01
影响因子：
3.8
通讯作者：
Rooney, N
中科院分区：
文献类型：
--
作者：
Meekin, SL;Glasgow, JFT;Rooney, N
在第二次随访研究中，对18名在儿童早期患有雷伊氏综合征（RS）的青少年进行了认知、情感和行为变量的评估。以西洋参为对照。在第一次随访研究中，整个RS组都存活了下来，没有明显的神经损伤。事实上，目前的研究结果表明，长期的认知，情感和行为功能与兄弟姐妹在大约一半的RS组。然而，有两个因素与不太有利的结果有关。认知，情绪和行为功能显着较差的亚组的幸存者的疾病发生在生命的第一年。此外，意识丧失虽然与不良结局的相关性不明显，但也与某些认知能力量表的相对缺陷相关。这些缺陷中有许多在第一次随访时并不明显，并考虑了神经发育因素的重要性。最后，这些研究结果的影响和RS等脑病的干预措施进行了讨论。
Eighteen adolescents who had survived Reye syndrome (RS) in early childhood were assessed on cognitive, emotional, and behavioural variables in a second follow-up study tracking this group. Siblings were used as controls. The entire group with RS had survived with no obvious neurological damage at the first follow-up study. Indeed, current findings suggested that long-term cognitive, emotional, and behavioural functioning was comparable to siblings in approximately half of the group with RS. However, two factors were associated with a less favourable outcome. Cognitive, emotional, and behavioural functioning were significantly poorer in the subgroup of survivors whose illness had occurred in the first year of life. In addition, loss of consciousness, although the association with poor outcome was not as noticeable, was also associated with relative deficits on some scales of cognitive ability. Many of these deficits had not been obvious at the first follow-up and the importance of neurodevelopmental factors are considered. Finally, the implications of these findings for research and interventions in RS and other such encephalopathies are discussed.