RACIAL (BLACK-WHITE) DIFFERENCES IN SERUM-LIPOPROTEIN (A) DISTRIBUTION AND ITS RELATION TO PARENTAL MYOCARDIAL-INFARCTION IN CHILDREN

DOI：

10.1161/01.cir.84.1.160

发表时间：

1991-07-01

期刊：

CIRCULATION

影响因子：

37.8

通讯作者：

中科院分区：

医学1区

文献类型：

作者：

SRINIVASAN, SR;DAHLEN, GH;BERENSON, GS

背景资料。脂蛋白(A)[Lp(A)]在生命早期预测冠状动脉疾病风险中的价值在不同种族中仍有待确定。对2,438名8-17岁混血儿的血清Lp(A)分布及其与父母心肌梗死病史的关系进行了研究。父母心肌梗死被用作后代未来疾病风险的替代测量。黑人的Lp(A)水平平均是白人的1.7倍(p&lt；0.0001)。在两个种族中都观察到了微小但显著的性别差异(女性大于男性，p&lt；0.05)。RACE是唯一对血清Lp(A)变异性有显著影响(9%)的自变量。有父母心肌梗死的白人儿童(n=90)的Lp(A)水平高于无父母心肌梗死的白人儿童(22.4 mg/dl和17.1 mg/dl，p&lt；0.01)。此外，在白人儿童中，Lp(A)水平大于25 mg/dl的儿童的父母心肌梗死的患病率高于那些Lp(A)水平低于25 mg/dl的儿童(9.5%对5.4%，p&lt；0.01)。相反，在黑人儿童中未发现Lp(A)与父母心肌梗死的关系。在任何种族的儿童中，未观察到亲代心肌梗死与血清中任何一种血脂或脂蛋白胆固醇水平的相关性。血清Lp(A)水平在评估白人人群早期冠状动脉疾病风险方面可能是有价值的。这些发现还强调了评估不同种族人群中Lp(A)致动脉粥样硬化的潜力的必要性。

Background. The value of lipoprotein (a) [Lp(a)] in the prediction of coronary artery disease risk very early in life remains to be established in different racial groups.Methods and Results. Serum Lp(a) distribution and its relation to parental histories of myocardial infarction were examined in 2,438 children (8-17 years old) from a biracial community. Parental myocardial infarction was used as a surrogate measure of future risk of disease in the offspring. Lp(a) levels averaged 1.7-fold higher in blacks than in whites (p < 0.0001). A small but significant sex difference (females greater than males, p < 0.05) was seen in both races. Race was the only independent variable that contributed appreciably (9%) to the variability of Lp(a) in serum. White children with parental myocardial infarction (n = 90) had increased levels of Lp(a) compared with those without parental myocardial infarction (22.4 versus 17.1 mg/dl, p < 0.01). Furthermore, among white children, the prevalence of parental myocardial infarction was higher in those with Lp(a) levels of more than 25 mg/dl than in those with values of 25 mg/dl or less (9.5% versus 5.4%, p < 0.01). In contrast, the relation of Lp(a) to parental myocardial infarction was not seen in black children. No associations were observed between parental myocardial infarction and serum levels of any of the lipids or lipoprotein cholesterol classes in children of either race.Conclusions. Serum Lp(a) levels may prove valuable in the assessment of coronary artery disease risk early in life among white populations. These findings also emphasize the need to evaluate the atherogenic potential of Lp(a) in different racial groups.

RACIAL (BLACK-WHITE) DIFFERENCES IN SERUM-LIPOPROTEIN (A) DISTRIBUTION AND ITS RELATION TO PARENTAL MYOCARDIAL-INFARCTION IN CHILDREN - BOGALUSA HEART-STUDY

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