Nocturnal ventilatory support in patients with cystic fibrosis: comparison with supplemental oxygen
Nocturnal ventilatory support in patients with cystic fibrosis: comparison with supplemental oxygen
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DOI：
10.1183/09031936.97.10091999
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发表时间：
1997-09-01
影响因子：
24.3
通讯作者：
Gozal, D
中科院分区：
文献类型：
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作者：
Gozal, D
囊性纤维化（CF）患者肺功能进行性恶化可导致明显的低氧血症和高碳酸血症，尤其是睡眠时，本文比较了6例CF患者应用双水平无创正压鼻罩通气（NIPPV）和低流量氧疗对呼吸和睡眠的影响（平均值+/-SD年龄22.3+/-4.7岁，患有严重肺部疾病（一秒用力呼气量（FEV 1）29.4+/-3.4%预测值）。与对照组相比，NIPPV和氧气治疗显著改善了快速眼动（REM）和非快速眼动（NREM）睡眠阶段的整体夜间氧饱和度。然而，氧疗期间经皮CO2张力显著增加，而NIPPV显著改善了所有睡眠状态下的肺泡通气，NIPPV和氧疗治疗夜期间睡眠结构和觉醒保持不变。我们得出结论，无创正压通气改善了严重囊性纤维化患者的睡眠相关低氧血症和高碳酸血症，而不影响睡眠。无创正压通气的长期依从性和益处尚不清楚。
Progressive deterioration of lung function in cystic fibrosis (CF) patients may lead to significant hypoxaemia and hypercapnia, especially during sleep.The effects of bilevel noninvasive positive pressure nasal mask ventilation (NIPPV) on respiration and sleep were compared to those of low-flow oxygen therapy in six CF patients (mean+/-SD age 22.3+/-4.7 yrs, with severe lung disease (forced expiratory volume in one second (FEV1) 29.4+/-3.4% predicted).Compared to the control night, NIPPV and oxygen therapy significantly improved overall night-time oxygen saturation during both rapid eye movement (REM) and non-rapid eye movement (NREM) sleep stages. However, significant increases in transcutaneous CO2 tension occurred during oxygen therapy, while NIPPV markedly improved alveolar ventilation during all sleep states, Sleep architecture and arousals remained unchanged during NIPPV and oxygen therapy treatment nights.We conclude that noninvasive positive pressure ventilation improves sleep-related hypoxaemia and hypercapnia in severe cystic fibrosis patients without affecting sleep, The long-term compliance and benefits of noninvasive positive pressure ventilation remain unclear.