Diffusion-weighted magnetic resonance imaging in the depiction of gastric cancer: initial experience
Diffusion-weighted magnetic resonance imaging in the depiction of gastric cancer: initial experience
复制标题
扩散加权磁共振成像在胃癌描述中的初步经验
DOI：
10.1007/s00261-015-0594-6
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发表时间：
2016-01-01
影响因子：
2.4
通讯作者：
Ji, Jia-Fu
中科院分区：
文献类型：
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作者：
Tang, Lei;Sun, Ying-Shi;Ji, Jia-Fu
本研究旨在探讨磁共振弥散加权成像（DW-MRI）在胃癌诊断中的可行性，并研究胃癌的信号特征和表观弥散系数（ADC）。为这项前瞻性研究制定了机构审查委员会批准的方案。对101例经胃镜活检证实的胃癌患者进行DW-MRI检查。确定DW-MRI的最佳激发次数（NEX），分析胃癌DW-MRI信号特征。由两位有经验的放射科医师独立测量胃癌的ADC值，并对测量结果进行Bland-Altman分析。当DW-MRI与四个NEX一起使用时，胃癌区域显示出良好的对比度和对比噪声比。在DW-MRI上观察到胃癌的4种信号特征：均匀高信号、内高外低信号（双层型）、高-低-高信号（三层夹心型）和混合型。由两名观察者测量的胃癌平均ADC值分别为（1.18 +/- 0.29）9 × 10（-3）mm（2）/s和（1.20 +/- 0.31）× 10（-3）mm（2）/s，与Bland-Altman分析显示出良好的一致性（95%一致性界限：-0.16至+0.19 × 10（-3）mm（2）/s）。胃癌在DW-MRI上具有不同的信号特征，ADC测量的重复性令人满意。DW-MRI有助于胃癌的显示。
The aim of the study was to explore the feasibility of diffusion-weighted magnetic resonance imaging (DW-MRI) in the depiction of gastric cancer and to investigate the signal characteristics and apparent diffusion coefficient (ADC) of gastric cancer. An institutional review board-approved protocol was developed for this prospective study. DW-MRI was performed on 101 patients with gastric cancer that was detected by gastroscopy biopsy. The optimal number of excitations (NEX) for DW-MRI was determined, and the signal characteristics of gastric cancer on DW-MRI were analyzed. The ADC of gastric cancer was measured by two experienced radiologists independently, and the reproducibility of measurement was investigated by the Bland-Altman analysis. When DW-MRI was used with four NEXs, areas of gastric cancer showed a good contrast and contrast-to-noise ratio. Four kinds of signal characteristics of gastric cancer were observed on DW-MRI: uniformly high signal, inner high signal, and outer low signal (two-layer type), high-low- high signal (three-layer sandwich type), and mixed type. The mean ADC of gastric cancer measured by two observers was (1.18 +/- 0.29) 9 10(-3) mm(2)/s and (1.20 +/- 0.31) x 10(-3) mm(2)/s respectively, which showed good agreement with Bland-Altman analysis (95% limits of agreement: -0.16 to +0.19 x 10(-3) mm(2)/s). Gastric cancers have various signal characteristics on DW-MRI and the reproducibility of ADC measurement is satisfactory. DW-MRI is helpful in the depiction of gastric cancer.