Anthryl-doped conjugated polyelectrolytes as aggregation-based sensors for nonquenching multicationic analytes
Anthryl-doped conjugated polyelectrolytes as aggregation-based sensors for nonquenching multicationic analytes
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DOI：
10.1021/ja075573r
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发表时间：
2007-12-26
影响因子：
15
通讯作者：
Swager, Timothy M.
中科院分区：
文献类型：
--
作者：
Satrijo, Andrew;Swager, Timothy M.
基于荧光的检测nonquenching，多阳离子小分子已被证明使用蓝色发光，聚阴离子聚（对苯乙炔）（PPE）掺杂绿色发光激子陷阱（蒽基单位）。多阳离子胺（精胺，亚精胺，和新霉素）被发现有效地诱导形成紧密相关的聚合物链之间的聚集体在溶液中。这种分析物诱导的聚集，伴随着PPE中增强的激子迁移，最终导致溶液中可见的蓝色至绿色荧光颜色变化。聚集为基础的传感器表现出对双阳离子和单阳离子胺的敏感性差，表明依赖于非特异性，静电相互作用的共轭双离子传感器仍然可以达到一定程度的选择性。
The fluorescence-based detection of nonquenching, multicationic small molecules has been demonstrated using a blue-emitting, polyanionic poly(p-phenylene ethynylene) (PPE) doped with green-emitting exciton traps (anthryl units). Multicationic amines (spermine, spermidine, and neomycin) were found to effectively induce the formation of tightly associated aggregates between the polymer chains in solution. This analyte-induced aggregation, which was accompanied by enhanced exciton migration in the PPE, ultimately led to a visually noticeable blue-to-green fluorescence color change in the solution. The aggregation-based sensor exhibited poor sensitivity toward dicationic and monocationic amines, demonstrating that a conjugated polyelectrolyte sensor relying on nonspecific, electrostatic interactions may still attain a certain level of selectivity.