Risk of endometrial cancer mortality by ever-use of sex hormones and other factors in Japan.
Risk of endometrial cancer mortality by ever-use of sex hormones and other factors in Japan.
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发表时间：
2006
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通讯作者：
Mmh Khan;M. Mori;F. Sakauchi;Khandoker Aklimunnessa;T. Kubo;Y. Fujino;Sadao Suzuki;S. Tokudome;Akiko Tamakosh
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作者：
Mmh Khan;M. Mori;F. Sakauchi;Khandoker Aklimunnessa;T. Kubo;Y. Fujino;Sadao Suzuki;S. Tokudome;Akiko Tamakosh
通过日本全国性协作队列研究，检查性激素（EUSH）和其他因素与子宫内膜癌（EC）死亡率的相关性。方法：1988-90年，从日本45个市政府招募了63，541名年龄在40-79岁的女性，随访至2003年，记录她们的生命状态。使用基线数据，使用考克斯比例风险模型（年龄校正和多变量）估计选定因素（包括EUSH）的EC死亡率的风险比（HR）和95%置信区间（CI）。还进行了双变量分析，以建立EUSH和其他因素之间的关联。结果在平均13.3年的随访期内，EC的死亡率为2.6/100，000人年。EUSH患病率为5.2%。年龄校正（HR=6.43，95%CI=2.10-19.67）和多变量（HR=5.33，95%CI=1.51-18.82）分析均发现EUSH患者EC死亡风险显著增加。双变量分析表明糖尿病史、吸烟、饮酒和初产年龄与EUSH呈正相关，而年龄、分娩次数、妊娠次数和初潮年龄呈负相关。结论：我们的研究结果表明，EUSH可能会增加日本妇女EC死亡率的风险。然而，需要更多死亡的进一步研究来验证结果。
OBJECTIVES To examine associations of ever-use of sex hormones (EUSH) and other factors with endometrial cancer (EC) mortality through a nation-wide Japan Collaborative Cohort Study. METHODS A total of 63,541 women aged 40-79 years, enrolled in 1988-90 from 45 municipalities of Japan, were followed until 2003 to record their vital status. Using baseline data, the Cox proportional hazard model (age adjusted and multivariate) was used to estimate the hazard ratio (HR) and 95% confidence interval (CI) for EC mortality by selected factors, including EUSH. Bivariate analysis was also conducted to establish associations between EUSH and other factors. RESULTS The mortality rate from EC was 2.6 per 100,000 person-years during the mean follow-up period of 13.3 years. Prevalence rate of EUSH was 5.2%. Significantly increased risk of EC mortality was found for EUSH with both age adjusted (HR=6.43, 95%CI=2.10-19.67) and multivariate (HR=5.33; 95%CI=1.51-18.82) analyses. Bivariate analysis indicated that history of diabetes mellitus, smoking, drinking, and age at first delivery were positively associated with EUSH, whereas age, number of delivery, number of pregnancy, and age at menarche demonstrated inverse links. CONCLUSIONS Our results imply that EUSH may increase the risk of EC mortality among Japanese women. However, further studies with more deaths are needed to validate the results.