Minicolumnar pathology in autism
Minicolumnar pathology in autism
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DOI：
10.1212/wnl.58.3.428
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发表时间：
2002-02-12
期刊：
影响因子：
9.9
通讯作者：
Roy, E
中科院分区：
文献类型：
--
作者：
Casanova, MF;Buxhoeveden, DP;Roy, E
目的：探讨孤独症患者和正常对照者脑微柱形态是否存在差异。背景资料：自闭症是一种严重的和普遍的儿童发育障碍，其特征是在社会交往和沟通方面的障碍，以及刻板的兴趣，活动和行为模式。死后的神经病理学研究仍然没有定论。研究方法：作者使用计算机成像程序测量了9名自闭症患者和对照组大脑颞叶内前额叶皮层9区和21区和后22区（Tpt）细胞柱形态特征的细节。结果如下：作者发现，自闭症患者和对照组的大脑在微柱数量、分隔细胞柱的水平间距以及内部结构（即细胞的相对分散度）方面存在显著差异。具体来说，自闭症患者大脑中的细胞柱数量更多，更小，更不紧凑：他们的细胞配置减少了周围的神经元空间。结论：在自闭症患者中，大脑额叶和颞叶存在微柱异常。
Objective: To determine whether differences exist in the configuration of minicolumns between the brains of autistic and control patients. Background: Autism is a severe and pervasive developmental disturbance of childhood, characterized by disturbances in both social interactions and communication, as well as stereotyped patterns of interests, activities, and behaviors. Postmortem neuropathologic studies remain inconclusive. Methods: The authors used a computerized imaging program to measure details of cell column morphologic features in area 9 of the prefrontal cortex and areas 21 and posterior 22 (Tpt) within the temporal lobe of nine brains of autistic patients and controls. Results: The authors found significant differences between brains of autistic patients and controls in the number of minicolumns, in the horizontal spacing that separates cell columns; and in their internal structure, that is, relative dispersion of cells. Specifically, cell columns in brains of autistic patients were more numerous, smaller, and less compact in: their cellular configuration with reduced neuropil space in the periphery. Conclusions: In autism, there are minicolumnar abnormalities in the frontal and temporal lobes of the brain.