A TYPOLOGICAL MODEL OF SCHIZOPHRENIA BASED ON AGE AT ONSET, SEX AND FAMILIAL MORBIDITY
A TYPOLOGICAL MODEL OF SCHIZOPHRENIA BASED ON AGE AT ONSET, SEX AND FAMILIAL MORBIDITY
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DOI：
10.1111/j.1600-0447.1994.tb01501.x
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发表时间：
1994-02-01
影响因子：
6.7
通讯作者：
KENDLER, KS
中科院分区：
文献类型：
--
作者：
SHAM, PC;MACLEAN, CJ;KENDLER, KS
我们调查了精神分裂症在男性和女性中的发病年龄分布，以及发病年龄和性别与精神分裂症和躁狂抑郁症家族发病率的关系，研究数据来自瑞典270名精神分裂症先证者的家庭研究。在对数尺度上，精神分裂症在男性和女性亲属中的发病年龄分布都是双峰的，这表明广义的精神分裂症可能是两种（可能相关的）疾病的混合物。无论先证者或亲属的性别如何，亲属患精神分裂症的风险随先证者发病年龄的变化而降低。相比之下，女性先证者的亲属中，年龄在20多岁的女性先证者患躁狂抑郁症的风险明显高于女性先证者的亲属中早、晚发病的女性先证者的亲属，以及男性先证者的亲属。这表明第三种疾病与情感性精神病有关，发病年龄中等，女性居多。
We investigated the age at onset distributions of schizophrenia in men and women and the relationship of age at onset and sex to the familial rates of schizophrenia and manic-depression in data from a Swedish family study of 270 schizophrenic probands. On the logarithmic scale, the age at onset distribution of schizophrenia in both male and female relatives was bimodal, suggesting that broadly defined schizophrenia may be a mixture of 2 (probably related) disorders. The risk of schizophrenia in relatives decreased as a function of the age at onset of the proband, irrespective of the sex of the proband or relative. In contrast, the risk of manic-depression was significantly higher in relatives of female probands with an age at onset in the twenties than in relatives of female probands with earlier or later onset, or in relatives of male probands. This suggests a third disorder related to affective psychosis, with an intermediate age at onset and female preponderance.