Aspermytin A:: a new neurotrophic polyketide isolated from a marine-derived fungus of the genus Aspergillus
Aspermytin A:: a new neurotrophic polyketide isolated from a marine-derived fungus of the genus Aspergillus
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DOI：
10.1016/j.bmcl.2003.10.053
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发表时间：
2004-01-19
影响因子：
2.7
通讯作者：
Ohta, T
中科院分区：
文献类型：
--
作者：
Tsukamoto, S;Miura, S;Ohta, T
从海洋真菌Aspergillus sp.中分离得到一个新的聚酮化合物aspermytin A（1），是从贻贝中分离出来的。根据它们的光谱数据确定了其结构，并通过圆二色光谱确定了I的绝对构型。在50 μ M的浓度下，在大鼠嗜铬细胞瘤（PC-12）细胞中，阿糖胞苷A诱导神经突生长。(C)2003 Elsevier Ltd.保留所有权利。
A new polyketide, aspermytin A (1), was isolated from a cultured marine fungus, Aspergillus sp., which was separated from the mussel, Mytilus edulis. Its structure was elucidated on the basis of their spectral data, and the absolute configuration of I was determined by the CD spectrum. Aspermytin A induced neurite outgrowth in rat pheochromocytoma (PC-12) cells at concentration of 50muM. (C) 2003 Elsevier Ltd. All rights reserved.