Activation of the basal ganglia and indirect pathway neurons during frontal lobe seizures
Activation of the basal ganglia and indirect pathway neurons during frontal lobe seizures
复制标题
额叶癫痫发作时激活基底神经节和间接通路神经元
DOI：
10.1093/brain/awab119
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发表时间：
2021-03-17
期刊：
影响因子：
14.5
通讯作者：
Kapur, Jaideep
中科院分区：
文献类型：
--
作者：
Brodovskaya, Anastasia;Shiono, Shinnosuke;Kapur, Jaideep
额叶运动性癫痫发作时神经元回路的活动没有详细的描述。利用活动报告小鼠、局部场电位记录、组织清除、病毒示踪和超分辨率显微镜，我们发现在纹状体、苍白球外、丘脑底核、黑质网状部和间接通路的神经元中，在局灶性运动至双侧强直-阵挛性癫痫发作后，神经元激活。它们有不同的投影。此外，D2受体激动剂注入纹状体产生抗惊厥作用。癫痫发作通过短潜伏期和长潜伏期回路激活结构，并且癫痫发作病灶的解剖学连接决定癫痫发作回路。这些研究首次在细胞水平上显示额叶运动性癫痫发作期间纹状体、苍白球、丘脑底核和黑质中的神经元的激活，揭示了受基底神经节调制的复杂神经元激活回路。
There are no detailed descriptions of neuronal circuit active during frontal lobe motor seizures. Using activity reporter mice, local field potential recordings, tissue clearing, viral tracing, and super-resolution microscopy, we found neuronal activation after focal motor to bilateral tonic-clonic seizures in the striatum, globus pallidus externus, subthalamic nucleus, substantia nigra pars reticulata and neurons of the indirect pathway.Seizures preferentially activated dopamine D2 receptor-expressing neurons over D1 in the striatum, which have different projections. Furthermore, the D2 receptor agonist infused into the striatum exerted an anticonvulsant effect. Seizures activate structures via short and long latency loops, and anatomical connections of the seizure focus determine the seizure circuit.These studies, for the first time, show activation of neurons in the striatum, globus pallidus, subthalamic nucleus, and substantia nigra during frontal lobe motor seizures on the cellular level, revealing a complex neuronal activation circuit subject to modulation by the basal ganglia.