The International College of Neuro-Psychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 2: Review, Grading of the Evidence, and a Precise Algorithm.
The International College of Neuro-Psychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 2: Review, Grading of the Evidence, and a Precise Algorithm.
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DOI：
10.1093/ijnp/pyw100
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发表时间：
2017-02-01
期刊：
影响因子：
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通讯作者：
Moeller HJ
中科院分区：
文献类型：
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作者：
Fountoulakis KN;Yatham L;Grunze H;Vieta E;Young A;Blier P;Kasper S;Moeller HJ
目前的论文包括对文献的系统检索，对结果的详细介绍，以及根据疗效和耐受性/安全性对治疗方案进行分级。文献检索使用PRISMA方法，将“双相”、“躁狂”、“躁狂”、“躁狂抑郁症”和“躁狂抑郁症”与“随机”相结合，并将“算法”与“躁狂”、“躁狂”、“双相”、“躁狂抑郁症”或“躁狂抑郁症”相结合。相关网页及评论文章亦已审阅。本报告是基于对截至2016年3月25日的57篇指南论文和531篇已发表的与随机对照试验、综述、后thoc或荟萃分析相关的论文的分析。对急性躁狂、混合发作、急性双相抑郁、维持期、精神病性和混合特征、焦虑和快速循环的具体治疗方案进行疗效评估。还审查了现有的治疗指南。最后，创建了反映疗效和推荐水平的表格，从而开发了一种精确的算法，但仍需在日常临床实践中证明其可行性。对双相情感障碍的药物治疗进行了系统的文献检索，以确定与双相情感障碍各方面有关的所有相关随机对照试验，并根据预先确定的方法对数据进行分级，以制定针对双相情感障碍各阶段管理的精确治疗算法。值得注意的是，治疗算法中的一些建议是基于事后分析的次要结果数据。
The current paper includes a systematic search of the literature, a detailed presentation of the results, and a grading of treatment options in terms of efficacy and tolerability/safety. The PRISMA method was used in the literature search with the combination of the words ‘bipolar,’ ‘manic,’ ‘mania,’ ‘manic depression,’ and ‘manic depressive’ with ‘randomized,’ and ‘algorithms’ with ‘mania,’ ‘manic,’ ‘bipolar,’ ‘manic-depressive,’ or ‘manic depression.’ Relevant web pages and review articles were also reviewed. The current report is based on the analysis of 57 guideline papers and 531 published papers related to RCTs, reviews, posthoc, or meta-analysis papers to March 25, 2016. The specific treatment options for acute mania, mixed episodes, acute bipolar depression, maintenance phase, psychotic and mixed features, anxiety, and rapid cycling were evaluated with regards to efficacy. Existing treatment guidelines were also reviewed. Finally, Tables reflecting efficacy and recommendation levels were created that led to the development of a precise algorithm that still has to prove its feasibility in everyday clinical practice. A systematic literature search was conducted on the pharmacological treatment of bipolar disorder to identify all relevant random controlled trials pertaining to all aspects of bipolar disorder and graded the data according to a predetermined method to develop a precise treatment algorithm for management of various phases of bipolar disorder. It is important to note that the some of the recommendations in the treatment algorithm were based on the secondary outcome data from posthoc analyses.