Metabolic fibroblast growth factors (FGFs): Mediators of energy homeostasis.
Metabolic fibroblast growth factors (FGFs): Mediators of energy homeostasis.
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DOI：
10.1016/j.semcdb.2015.09.021
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发表时间：
2016-05
影响因子：
7.3
通讯作者：
Potthoff MJ
中科院分区：
文献类型：
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作者：
Markan KR;Potthoff MJ
代谢性成纤维细胞生长因子（FGFs）、FGF1、FGF15/19和FGF21不同于传统的FGFs，它们调节能量稳态以响应波动的营养可用性。这些独特的代谢介质调节了许多生理过程，这些生理过程有助于其有效的药理特性。在肥胖动物模型中，这些fgf的药理学剂量可导致体重减轻，增加能量消耗，并改善碳水化合物和脂质代谢。然而，关于控制个体代谢性FGFs作用的精确分子和生理机制，仍然存在许多问题。在这里，我们回顾了FGF1， FGF15/19和FGF21的代谢作用，同时通过检查已知的生物学功能提供了对其药理作用的见解。
The metabolic fibroblast growth factors (FGFs), FGF1, FGF15/19, and FGF21 differ from classic FGFs in that they modulate energy homeostasis in response to fluctuating nutrient availability. These unique mediators of metabolism regulate a number of physiological processes which contribute to their potent pharmacological properties. Administration of pharmacological doses of these FGFs causes weight loss, increases energy expenditure, and improves carbohydrate and lipid metabolism in obese animal models. However, many questions remain regarding the precise molecular and physiological mechanisms governing the effects of individual metabolic FGFs. Here we review the metabolic actions of FGF1, FGF15/19, and FGF21 while providing insights into their pharmacological effects by examining known biological functions.