Inflammatory Bowel Disease and the Risk of Prostate Cancer
Inflammatory Bowel Disease and the Risk of Prostate Cancer
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DOI：
10.1016/j.eururo.2018.11.039
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发表时间：
2019-05-01
期刊：
影响因子：
23.4
通讯作者：
Kundu, Shilajit D.
中科院分区：
文献类型：
--
作者：
Burns, Jacob A.;Weiner, Adam B.;Kundu, Shilajit D.
背景：研究炎症性肠病(IBD)患者前列腺癌(PCA)风险的数据有限。目的：比较炎症性肠病(IBD)患者和非IBD患者前列腺癌(PCa)的发生率。设计、环境和参与者：这是一项涉及单个学术医学中心的回顾性配对队列研究，从1996年到2017年进行。男性IBD患者(病例=1033例)按年龄和种族随机配对，与非IBD男性(对照组=9306)进行1：9配对。所有患者都接受了至少一次前列腺特异性抗原(PSA)筛查。结果测量和统计分析：Kaplan-Meier和多变量Cox比例风险模型，按年龄和种族分层，评估IBD与任何PCa和临床显著PCa(Gleason分级组=2)的关系。结果与局限性：10岁时IBD患者的PCa发生率为4.4%，对照组为0.65%(危险比[HR]4.84[3.34-7.02][3.19-6.69]，p<0.05)。
Background: There are limited data examining the risk of prostate cancer (PCa) in patients with inflammatory bowel disease (IBD).Objective: To compare the incidence of PCa between men with and those without IBD.Design, setting, and participants: This was a retrospective, matched-cohort study involving a single academic medical center and conducted from 1996 to 2017. Male patients with IBD (cases = 1033) were randomly matched 1:9 by age and race to men without IBD (controls = 9306). All patients had undergone at least one prostate-specific antigen (PSA) screening test.Outcome measurements and statistical analysis: Kaplan-Meier and multivariable Cox proportional hazard models, stratified by age and race, evaluated the relationship between IBD and the incidence of any PCa and clinically significant PCa (Gleason grade group >= 2). A mixed-effect regression model assessed the association of IBD with PSA level.Results and limitations: PCa incidence at 10 yr was 4.4% among men with IBD and 0.65% among controls (hazard ratio [HR] 4.84 [3.34-7.02] [3.19-6.69], p