PROLONGED INCREASE IN INSULIN-STIMULATED GLUCOSE-TRANSPORT IN MUSCLE AFTER EXERCISE
PROLONGED INCREASE IN INSULIN-STIMULATED GLUCOSE-TRANSPORT IN MUSCLE AFTER EXERCISE
复制标题
DOI：
10.1152/ajpendo.1989.256.4.e494
复制
发表时间：
1989-04-01
影响因子：
--
通讯作者：
HOLLOSZY, JO
中科院分区：
文献类型：
--
作者：
CARTEE, GD;YOUNG, DA;HOLLOSZY, JO
运动可以诱导骨骼肌葡萄糖转运对胰岛素的敏感性和反应性的短期增加。本研究的目的是确定碳水化合物剥夺对运动后胰岛素敏感性和反应性持续增加的影响。运动3小时后，碳水化合物剥夺（脂肪喂养）大鼠的上滑车肌对最大胰岛素刺激的3-O-甲基葡萄糖（3-MG）转运比未运动大鼠的肌肉增加了25%;运动后18小时，胰岛素反应性的增加被逆转。运动后3 h，喂食碳水化合物的大鼠肌肉胰岛素反应性没有增加。在运动后3小时研究的肌肉中，60 μ U/ml胰岛素对3-MG转运的作用大约是未运动对照的两倍，与饮食碳水化合物摄入无关。这种胰岛素敏感性的增加在碳水化合物喂养的大鼠中在18小时内消失，但在碳水化合物剥夺的大鼠中持续至少48小时。运动后，在喂食碳水化合物18小时的大鼠中肌糖原增加约41 μ mol/g，而在喂食脂肪48小时的大鼠中仅增加约14.5 μ mol/g。碳水化合物剥夺大鼠运动后胰岛素敏感性的持续增加与热量摄入无关，因为禁食和脂肪喂养大鼠的肌肉表现相似。
Exercise can induce short-term increases in the sensitivity and responsiveness of skeletal muscle glucose transport to insulin. The purpose of this study was to determine the effect of carbohydrate deprivation on the persistence of increased insulin sensitivity and responsiveness after a bout of exercise. Three hours after about of exercise, epitrochlearis muscles from carbohydrate-deprived (fat fed) rats shwoed a 25% greater increase in 3-O-methylglucose (3-MG) transport in response to a maximal insulin stimulus compared with muscles of nonexercised rats; this increase in insulin responsiveness had reversed 18 h postexercise. Muscles of rats fed carbohydrate showed no increase in insulin responsiveness 3 h after exercise. The effect of 60 .mu.U/ml of insulin on 3-MG transport was approximately twofold greater in muscles studied 3 h after exercise than in nonexercised controls regardless of dietary carbohydrate intake. This increase in insulin sensitivity was lost within 18 h in carbohydrate-fed rats but persisted for at least 48 h in carbohydrate-deprived rats. Muscle glycogen increased .apprx.41 .mu.mol/g in the rats fed carbohydrate for 18 h, and only .apprx.14.5 .mu.mol/g in the rats fed fat for 48 h, after exercise. The persistent increase in insulin sensitivity after excercise in carbohydrate-deprived rats was unrelated to caloric intake, as muscles of fasted and fat-fed rats behaved similarly.