Gd-EOB-DTPA-enhanced MRI for the assessment of liver function and volume in liver cirrhosis
Gd-EOB-DTPA-enhanced MRI for the assessment of liver function and volume in liver cirrhosis
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DOI：
10.1259/bjr.20120653
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发表时间：
2013-06-01
影响因子：
2.6
通讯作者：
Jonas, E.
中科院分区：
文献类型：
--
作者：
Nilsson, H.;Blomqvist, L.;Jonas, E.
目的：本研究旨在利用动态肝细胞特异性对比增强MRI评估肝硬化患者的肝脏体积和功能，并将结果与标准评分模型相关联，探讨肝硬化患者肝功能分布的不均匀性。方法：纳入10例肝硬化患者和20名健康志愿者作为对照。使用反卷积分析逐个体素地计算肝提取分数（HEF）、输入相对血流量和平均通过时间。计算以HEFml表示的节段和总肝脏体积以及节段和总肝提取能力。构建不一致评分（IS）来反映肝功能的不均匀分布。采用Mann-Whitney U检验对定量肝功能参数、肝脏体积和ISs进行组间比较。使用 Spearman 等级相关性评估肝功能参数与临床评分之间的相关性。结果：与健康对照相比，患者的实质肝体积较大，肝细胞功能较低，功能分布更不均匀。结论：该研究证明了肝硬化的非均质性，并强调了肝功能测试能够补偿肝脏不均匀分布的必要性。 知识进展：该研究描述了一种定量评估肝脏整体和分段水平上钆塞酸或乙氧基苄基二亚乙基三胺五乙酸钆的肝脏吸收情况的新方法。
Objective: The aims of this study were to use dynamic hepatocyte-specific contrast-enhanced MRI to evaluate liver volume and function in liver cirrhosis, correlate the results with standard scoring models and explore the inhomogeneous distribution of liver function in cirrhotic livers.Methods: 10 patients with liver cirrhosis and 20 healthy volunteers, serving as controls, were included. Hepatic extraction fraction (HEF), input relative blood flow and mean transit time were calculated on a voxel-by-voxel basis using deconvolutional analysis. Segmental and total liver volumes as well as segmental and total hepatic extraction capacity, expressed in HEFml, were calculated. An incongruence score (IS) was constructed to reflect the uneven distribution of liver function. The Mann-Whitney U-test was used for group comparison of the quantitative liver function parameters, liver volumes and ISs. Correlations between liver function parameters and clinical scores were assessed using Spearman rank correlation.Results: Patients had larger parenchymal liver volume, lower hepatocyte function and more inhomogeneous distribution of function compared with healthy controls.Conclusion: The study demonstrates the non-homogeneous nature of liver cirrhosis and underlines the necessity of a liver function test able to compensate for the heterogeneous distribution of liver function in patients with diseased liver parenchyma.Advances in knowledge: The study describes a new way to quantitatively assess the hepatic uptake of gadoxetate or gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid in the liver as a whole as well as on a segmental level.