Perspectives in immunotherapy: meeting report from the "Immunotherapy Bridge" (December 4th-5th, 2019, Naples, Italy).

Perspectives in immunotherapy: meeting report from the "Immunotherapy Bridge" (December 4th-5th, 2019, Naples, Italy).
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DOI:
10.1186/s12967-020-02627-y
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发表时间:
2021-01-06
影响因子:
7.4
通讯作者:
Puzanov I
Puzanov I
中科院分区:
医学2区
文献类型:
--
作者:
Ascierto PA;Butterfield LH;Campbell K;Daniele B;Dougan M;Emens LA;Formenti S;Janku F;Khleif SN;Kirchhoff T;Morabito A;Najjar Y;Nathan P;Odunsi K;Patnaik A;Paulos CM;Reinfeld BI;Skinner HD;Timmerman J;Puzanov I

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在过去的几年里,许多临床试验和现实世界的经验提供了大量的证据,证明了免疫治疗药物在各种恶性肿瘤中长期生存的潜力,从黑色素瘤开始,扩展到其他肿瘤。免疫检查点阻断的临床成功鼓励了其他免疫疗法的不断发展。据估计,目前有超过3000项免疫肿瘤学试验正在进行中,针对数百种疾病和免疫途径。关于癌症免疫治疗的不断发展的主题,包括各种恶性肿瘤免疫治疗的最新技术水平,是免疫治疗桥会议(2019年12月4日至5日,意大利那不勒斯)的讨论重点,并在本报告中进行了总结。
Over the last few years, numerous clinical trials and real-world experience have provided a large amount of evidence demonstrating the potential for long-term survival with immunotherapy agents across various malignancies, beginning with melanoma and extending to other tumours. The clinical success of immune checkpoint blockade has encouraged increasing development of other immunotherapies. It has been estimated that there are over 3000 immuno-oncology trials ongoing, targeting hundreds of disease and immune pathways. Evolving topics on cancer immunotherapy, including the state of the art of immunotherapy across various malignancies, were the focus of discussions at the Immunotherapy Bridge meeting (4–5 December, 2019, Naples, Italy), and are summarised in this report.
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