Experimental investigations on carbon ion scanning radiography using a range telescope
Experimental investigations on carbon ion scanning radiography using a range telescope
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使用测距望远镜进行碳离子扫描射线照相的实验研究
DOI：
10.1088/0031-9155/59/12/3041
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发表时间：
2014
影响因子：
3.5
通讯作者：
Parodi K
中科院分区：
文献类型：
--
作者：
Rinaldi I;Brons S;Jäkel O;Voss B;Parodi K
离子束由于其倒置的深度-剂量分布和在组织中的有限范围（布拉格峰（BP））而提供优良的肿瘤剂量保形性。然而，它们引入了对范围不确定性的敏感性。成像技术在离子束治疗中发挥着越来越重要的作用，以支持在计划阶段精确诊断和识别靶体积，以及确保在实际照射时计划和治疗情况之间的对应关系。为了提高治疗质量，可以在治疗之前或治疗期间在治疗部位处采集基于离子的放射照相图像，并将其用于监测患者定位和检查患者特异性离子范围。这项工作提出了初步的实验研究进行，以解决在海德堡离子治疗中心使用原型范围望远镜设置和主动光栅扫描离子束传输系统的碳离子射线照相的可行性。布拉格曲线的测量与电离室（IC）的堆栈同步的光束传输。BP的位置是通过定位每个传输射束的最大电流信号的通道从数据中提取的。每个BP与从射束监视器系统外推的扫描光栅点的横向和垂直位置相关联，以建立射线照相术。基于探测器的两次校准，将射线照相图像转换为水当量厚度（WET）。对两种不同复杂度的体模的X线片进行了重建，并分析了其图像质量。提出了一种新的方法，以提高标称范围的分辨率的IC堆栈应用到碳离子造影的Alderson头体模。此外，通过临床使用的离子范围校准曲线将相同拟人头部体模的X射线数字重建摄影转换为WET，并与基于γ指数方法的碳离子摄影进行比较，在± 3%的绝对WET、3 mm的一致性距离和87%的通过率方面产生了良好的对应关系。由于光束的有限尺寸，导致多个最大值，在辐照体模内的接口处的成像伪影得到解决。总体而言，这项工作表明了原型范围望远镜的可行性，以获得基于离子的传输成像分辨率高达0.8毫米湿。
Ion beams offer an excellent tumor-dose conformality due to their inverted depth-dose profile and finite range in tissue, the Bragg peak (BP). However, they introduce sensitivity to range uncertainties. Imaging techniques play an increasingly important role in ion beam therapy to support precise diagnosis and identification of the target volume at the planning stage as well as to ensure the correspondence between the planning and treatment situation at the actual irradiation. For the purpose of improved treatment quality, ion-based radiographic images could be acquired at the treatment site before or during treatment and be employed to monitor the patient positioning and to check the patient-specific ion range. This work presents the initial experimental investigations carried out to address the feasibility of carbon ion radiography at the Heidelberg ion therapy center using a prototype range telescope set-up and an active raster scanning ion beam delivery system. Bragg curves are measured with a stack of ionization chambers (IC) synchronously to the beam delivery. The position of the BP is extracted from the data by locating the channel of maximum current signal for each delivered beam. Each BP is associated to the lateral and vertical positions of the scanned raster point extrapolated from the beam monitor system to build up a radiography. The radiographic images are converted into water equivalent thickness (WET) based on two calibrations of the detector. Radiographies of two phantoms of different complexities are reconstructed and their image quality is analyzed. A novel method proposed to increase the nominal range resolution of the IC stack is applied to the carbon ion radiography of an Alderson head phantom. Moreover, an x-ray digitally reconstructed radiography of the same anthropomorphic head phantom is converted in WET through the clinically used ion range calibration curve and compared with the carbon ion radiography based on a γ-index approach, yielding a good correspondence in terms of absolute WET within±3%, 3 mm distance-to-agreement and, 87% passing ratio. Imaging artifacts at interfaces within the irradiated phantom due to the finite size of the beam, resulting in multiple maxima, are addressed. Overall, this work demonstrates the feasibility of the prototype range telescope to acquire ion-based transmission imaging with a resolution of up to 0.8 mm WET.
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影响因子：
3.8
作者：
Jäkel, O;Jacob, C;Hartmann, GH
通讯作者：
Hartmann, GH
一种提高平行板电离室堆叠标称距离分辨率的方法
影响因子：
3.5
作者：
Rinaldi I;Brons S;Jäkel O;Voss B;Parodi K
通讯作者：
Parodi K
粒子射线照相和自动激活。
DOI：
--
发表时间：
1977
期刊：
International Journal of Radiation Oncology, Biology, Physics
影响因子：
--
作者：
C. Tobias;E. Benton;M. Capp;A. Chatterjee;M. R. Cruty;R. P. Henke
通讯作者：
R. P. Henke
高能放射性粒子束诊断成像：布拉格峰癌症治疗中的应用。
DOI：
--
发表时间：
1997
期刊：
Nuclear Physics
影响因子：
--
作者：
A. Chatterjee;E. Takada;M. Torikoshi;Mitsutaka Kanazawa
通讯作者：
Mitsutaka Kanazawa
使用重离子 CT 测量电子密度分布
DOI：
--
发表时间：
2004
期刊：
影响因子：
--
作者：
Y. Ohno;T. Kohno;N. Matsufuji;T. Kanai
通讯作者：
T. Kanai