Simultaneous detection of single-nucleotide polymorphisms in a DNA bulge structure using fluorine-modified bisbenzimide derivative
Simultaneous detection of single-nucleotide polymorphisms in a DNA bulge structure using fluorine-modified bisbenzimide derivative
复制标题
使用氟修饰双苯甲亚胺衍生物同时检测 DNA 凸起结构中的单核苷酸多态性
DOI：
10.1039/c5an02389k
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发表时间：
2016
期刊：
影响因子：
4.2
通讯作者：
Kenzo Fujimoto
中科院分区：
文献类型：
--
作者：
Takashi Sakamoto;Daisaku Hasegawa;Kenzo Fujimoto
Using 3,5-bis(trifluoromethyl)benzene-modified bisbenzimide H33258, bulged-out nucleobases on a DNA strand can be detected by the chemical shift change in 19F NMR. Based on this technique, single-nucleotide polymorphisms on a DNA sequence can be analyzed simultaneously.
