Attention and memory-related responses of neurons in the lateral intraparietal area during spatial and shape-delayed match-to-sample tasks.
Attention and memory-related responses of neurons in the lateral intraparietal area during spatial and shape-delayed match-to-sample tasks.
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在空间和形状延迟匹配样本任务期间，外侧顶叶区域神经元的注意力和记忆相关反应。
DOI：
10.1152/jn.00431.2005
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发表时间：
2006
期刊：
影响因子：
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通讯作者：
Amador,SilviaC
中科院分区：
文献类型：
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作者：
Sereno,AnneB;Amador,SilviaC
当猴子注意、记忆和注视目标时，外侧顶叶内区（LIP）的一些神经元的活动发生了变化。我们记录了在空间和形状匹配样本任务中分离的神经元，以检查和表征LIP的自愿活动过程。许多LIP神经元在延迟期间表现出空间选择性活动，这取决于样本的位置，但对于大多数细胞来说，这种活动在两个任务之间没有区别。尽管过去许多关于后顶叶皮层的研究已经从决策和运动计划等主动过程的角度解释了该区域的反应，但我们的研究结果表明，该区域的大部分活动代表了更多的被动处理。尽管如此，我们确实看到了在延迟期间表现出指令依赖活动的显著少数单元，这表明这些单元可能代表了自愿或主动过程的神经相关。另外，我们发现在样品刺激和测试阵列的呈现过程中，当动物必须注意刺激的形状时，某些单元对形状匹配任务中的刺激表现出更强的反应。在形状任务中对样本的这种升高的反应为LIP中基于特征的注意提供了证据。对形状的注意是一种在灵长类动物皮层中从未被描述过的特性。
When a monkey attends to, remembers, and looks toward targets, the activity of some neurons in the lateral intraparietal area (LIP) changes. We recorded from isolated neurons during both a spatial and a shape match-to-sample task to examine and characterize voluntary active processes in LIP. Many LIP neurons show spatially selective activity during the delay period that depends on the location of the sample, but for most cells, this activity doesnotdiffer between the two tasks. Although much past work in posterior parietal cortex has explained responses in this region in terms of active processes such as decision-making and motor planning, our findings suggest that much of that activity represents more passive processing. Nevertheless, we do see a significant minority of units that demonstrate instruction-dependent activity during the delay period, suggesting that these units could represent the neural correlates of voluntary or active processes. Separately, we found that during the presentation of the sample stimulus and test array, some units show stronger responses to the stimulus in the shape-matching task when the animal must attend to the shape of a stimulus. This elevated response to the sample during the shape task provides evidence for feature-based attention in LIP. Attention to shape is a property that has not previously been described in primate cortex.