Anionic C-Terminal Proregion of Nematode Antimicrobial Peptide Cecropin P4 Precursor Inhibits Antimicrobial Activity of the Mature Peptide
Anionic C-Terminal Proregion of Nematode Antimicrobial Peptide Cecropin P4 Precursor Inhibits Antimicrobial Activity of the Mature Peptide
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DOI：
10.1271/bbb.80397
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发表时间：
2008-12-01
影响因子：
1.6
通讯作者：
Kato, Yusuke
中科院分区：
文献类型：
--
作者：
Ueno, Satoshi;Kusaka, Kohtaro;Kato, Yusuke
最近，一个阴离子proregion被发现是保守的抗菌肽，线虫cecropin的C端。我们的研究结果表明，成熟肽的抗菌活性被其前体中的前区抑制，并在加工后从抑制中释放。抑制不太可能是由于膜破坏的直接抑制。
Recently, an anionic proregion was found to be conserved at the C terminus of the antimicrobial peptide, nematode cecropin. Our results suggest that the antimicrobial activity of mature peptide is suppressed by the proregion in its precursor and is released from inhibition after processing. Inhibition is not likely to be due to direct suppression of membrane disruption.