RADIOLOGIC ABNORMALITIES AND AUTONOMIC NEUROPATHOLOGY IN THE DIGESTIVE-TRACT OF THE KETONURIC DIABETIC CHINESE-HAMSTER
RADIOLOGIC ABNORMALITIES AND AUTONOMIC NEUROPATHOLOGY IN THE DIGESTIVE-TRACT OF THE KETONURIC DIABETIC CHINESE-HAMSTER
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DOI：
10.1007/bf01222975
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发表时间：
1979-01-01
期刊：
影响因子：
8.2
通讯作者：
GERRITSEN, GC
中科院分区：
文献类型：
--
作者：
DIANI, AR;GROGAN, DM;GERRITSEN, GC
糖尿病中国仓鼠的X线表现为胃、小肠和大肠明显扩张。小肠和大肠中Ba的絮凝表现为运动功能减退。通过时间受损的进一步特征为胃排空延长（糖尿病患者平均570分钟;对照组200分钟）和粪便形成延迟（糖尿病患者平均230分钟;对照组100分钟）和通过延迟（糖尿病患者平均457分钟;对照组210分钟）。小肠Auerbach肌间神经丛的超微结构分析表明某些远端无髓鞘轴突发生急性变性。肿胀，糖原沉积，神经丝聚集，板层体密集。神经元轴突中钡絮状物、糖原沉积、神经丝聚集和板层包涵体的严重程度和频率与酮尿症的持续时间直接相关。奥尔巴赫丛的自主神经病理学可能是酮尿型糖尿病中国仓鼠胃肠道功能障碍的一个关键因素。
X-ray patterns of ketonuric diabetic Chinese hamsters displayed marked dilatation of the stomach, small and large intestine. Hypomotility was manifested by flocculation of Ba in the small and large bowel. Impaired transit time was further characterized by prolonged emptying of the stomach (mean 570 min diabetics; 200 min controls) and delayed stool formation (mean 230 min diabetics; and 100 min controls) and passage (mean 457 min diabetics; 210 min controls). Ultrastructural analysis of Auerbach''s myenteric plexuses of the small intestine indicated acute degeneration in certain distal, unmyelinated axons. Swelling, deposition of glycogen, aggregation of neurofilaments and dense accumulation of lamellar bodies were observed. The severity and frequency of Ba flocculation, glycogen deposition, aggregation of neurofilaments and lamellar inclusion bodies in axons were directly related to duration of ketonuria. Autonomic neuropathology in Auerbach plexuses may be a critical factor underlying gastrointestinal dysfunction in the ketonuric diabetic Chinese hamster.