The BBZDR/Wor rat model for investigating the complications of type 2 diabetes mellitus
The BBZDR/Wor rat model for investigating the complications of type 2 diabetes mellitus
复制标题
DOI：
10.1093/ilar.45.3.292
复制
发表时间：
2004-01-01
期刊：
影响因子：
2.5
通讯作者：
Guberski, DL
中科院分区：
文献类型：
--
作者：
Tirabassi, RS;Flanagan, JF;Guberski, DL
同系和近交系的大鼠为研究人员提供了宝贵的洞察糖尿病和相关并发症的发病机制。近交系Bio-Breeding Zucker糖尿病大鼠（BBZDR）/Wor大鼠品系是一种相对较新的2型糖尿病模型。该品系通过经典育种方法产生，所述方法用于将来自胰岛素抗性Zucker脂肪大鼠的缺陷性瘦素受体基因（Lepr（fa））渗入近交系BBDR/Wor品系背景中。糖尿病雄性BBZDR/Wor大鼠的脂肪突变是纯合的，并且具有原始BB品系的遗传背景。虽然瘦的同窝出生的大鼠是表型正常的，肥胖的幼年BBZDR/Wor大鼠是高血脂和高瘦素血症，成为胰岛素抵抗，并最终发展为高血糖症。此外，BBZDR/Wor大鼠具有免疫能力，不会发生自身免疫。与临床糖尿病患者相似，BBZDR/Wor大鼠出现与高血糖症相关的并发症。BBZDR/Wor大鼠是一种模型系统，完全具备研究影响人类2型糖尿病患者并发症的能力。在这篇综述中，最近的工作，评估2型糖尿病并发症的BBZDR/Wor大鼠进行了讨论，包括作者的初步未发表的研究心血管疾病。
Congenic and inbred strains of rats offer researchers invaluable insight into the etiopathogenesis of diabetes and associated complications. The inbred Bio-Breeding Zucker diabetic rat (BBZDR)/Wor rat strain is a relatively new and emerging model of type 2 diabetes. This strain was created by classical breeding methods used to introgress the defective leptin receptor gene (Lepr(fa)) from insulin-resistant Zucker fatty rats into the inbred BBDR/Wor strain background. The diabetic male BBZDR/Wor rat is homozygous for the fatty mutation and shares the genetic background of the original BB strain. Although lean littermates are phenotypically normal, obese juvenile BBZDR/Wor rats are hyperlipidemic and hyperleptinemic, become insulin resistant, and ultimately develop hyperglycemia. Furthermore, the BBZDR/Wor rat is immune competent and does not develop autoimmunity. Similar to patients with clinical diabetes, the BBZDR/Wor rat develops complications associated with hyperglycemia. The BBZDR/Wor rat is a model system that fully encompasses the ability to study the complications that affect human type 2 diabetic patients. In this review, recent work that has evaluated type 2 diabetic complications in BBZDR/Wor rats is discussed, including the authors' preliminary unpublished studies on cardiovascular disease.