EARLIEST CLINICAL AND HISTOLOGICAL-CHANGES IN PSORIASIS
EARLIEST CLINICAL AND HISTOLOGICAL-CHANGES IN PSORIASIS
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DOI：
10.1159/000250139
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发表时间：
1981-01-01
期刊：
影响因子：
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通讯作者：
RZESA, G
中科院分区：
文献类型：
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作者：
CHOWANIEC, O;JABLONSKA, S;RZESA, G
在89例活动性银屑病患者和10例正常志愿者中进行了研究。未受累皮肤面积10 ×10 cm大小的标记物，并密切观察14 d。在54例银屑病患者中，几乎在皮肤水平（表面无鳞屑）出现非常细小的丘疹，在观察过程中转变为典型的针尖状丘疹。组织学和组织化学研究表明，这些prepinpoint丘疹相当丰富的浸润组成的多形核。细胞渗入表皮，在角质层中形成局灶性小积聚。颗粒层变得萎缩或模糊，角质层是正角化的，没有表皮增生，即没有银屑病特征。免疫荧光研究显示体内固定的IG在约50%为针尖前丘疹，20%为补体。这些研究指出了多形核细胞在银屑病病变发展的最早阶段的作用。
Studies were performed in 89 patients with active psoriasis and in 10 normal volunteers. Areas of uninvolved skin 10 .times. 10 cm in size were demarcated and closely observed for 14 days. In 54 patients with psoriasis, very fine, erythematous papules developed almost at skin level (with no scaling of the surface), changing in the course of observation into typical pinpoint papules. Histological and histochemical studies of these prepinpoint papules revealed fairly abundant infiltrates composed largely of polymorphonuclears. The cells penetrated into the epidermis forming focally small accumulations in the stratum corneum. The granular layer became atrophied or blurred, the stratum corneum was orthokeratotic and there was no epidermal proliferation, i.e. no psoriatic features. Immunofluorescence studies showed in vivo fixed Ig in .apprx. 50% of prepinpoint papules and complement in 20% of them. The studies point to the role of polymorphonuclears in the earliest stages of the development of psoriatic lesions.