Stress and asthma: Novel insights on genetic, epigenetic, and immunologic mechanisms
Stress and asthma: Novel insights on genetic, epigenetic, and immunologic mechanisms
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DOI：
10.1016/j.jaci.2014.07.005
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发表时间：
2014-11-01
影响因子：
14.2
通讯作者：
Celedon, Juan C.
中科院分区：
文献类型：
--
作者：
Rosenberg, Stacy L.;Miller, Gregory E.;Celedon, Juan C.
在美国，经济上处于不利地位的人和一些少数族裔经常面临长期的心理社会压力，并特别受到哮喘的影响。目前的证据表明，慢性心理社会压力与哮喘或哮喘发病率之间存在因果关系。最近的发现表明了这种联系的潜在机制，包括调节行为、自主神经、神经内分泌和免疫反应的基因甲基化和表达的变化。也有证据表明，存在易感基因，使长期应激的年轻人容易患上创伤后应激障碍和哮喘。在这篇综述中，我们对已发表的证据进行了批判性的审查，并提出了该领域未来研究的方向。
In the United States the economically disadvantaged and some ethnic minorities are often exposed to chronic psychosocial stressors and disproportionately affected by asthma. Current evidence suggests a causal association between chronic psychosocial stress and asthma or asthma morbidity. Recent findings suggest potential mechanisms underlying this association, including changes in the methylation and expression of genes that regulate behavioral, autonomic, neuroendocrine, and immunologic responses to stress. There is also evidence suggesting the existence of susceptibility genes that predispose chronically stressed youth to both post-traumatic stress disorder and asthma. In this review we critically examine published evidence and suggest future directions for research in this field.