Intrinsic Network Connectivity Reflects Consistency of Synesthetic Experiences
Intrinsic Network Connectivity Reflects Consistency of Synesthetic Experiences
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DOI：
10.1523/jneurosci.5401-11.2012
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发表时间：
2012-05-30
影响因子：
5.3
通讯作者：
Riedl, Valentin
中科院分区：
文献类型：
--
作者：
Dovern, Anna;Fink, Gereon R.;Riedl, Valentin
研究联觉背后的认知过程——一种对一种感觉模式的刺激会自动导致异常的额外感觉知觉的情况，能够深入了解正常和异常跨模式感觉处理的神经机制。与联觉由过度连接导致的观点一致，对12名字形 - 颜色联觉者和12名非联觉对照受试者的静息态功能磁共振成像数据进行的功能连接性分析（采用独立成分分析和基于种子的相关性分析）显示，除了网络内连接性增强外，字形 - 颜色联觉在内在网络间连接性方面既有整体性的增加，也有特定的（内侧和外侧视觉网络到右侧额顶网络）增加。此外，这种内在网络连接性的增强反映了联觉体验的强度。这些发现构成了联觉中功能网络连接性增强的首个直接证据。
除了对理解联觉的神经机制有重大贡献外，我们的研究结果还具有重要的普遍意义。结合来自临床人群的数据，我们的数据有力地表明，内在网络连接性的改变差异与人类体验的现象学直接相关。
Studying cognitive processes underlying synesthesia, a condition in which stimulation of one sensory modality automatically leads to abnormal additional sensory perception, allows insights into the neural mechanisms of normal and abnormal cross-modal sensory processing.Consistent with the notion that synesthesia results from hyperconnectivity, functional connectivity analysis (adopting independent component analysis and seed-based correlation analysis) of resting-state functional magnetic resonance imaging data of 12 grapheme-color synesthetes and 12 nonsynesthetic control subjects revealed, in addition to increased intranetwork connectivity, both a global and a specific (medial and lateral visual networks to a right frontoparietal network) increase of intrinsic internetwork connectivity in grapheme-color synesthesia. Moreover, this increased intrinsic network connectivity reflected the strength of synesthetic experiences. These findings constitute the first direct evidence of increased functional network connectivity in synesthesia.In addition to this significant contribution to the understanding of the neural mechanisms of synesthesia, our results have important general implications. In combination with data derived from clinical populations, our data strongly suggest that altered differences in intrinsic network connectivity are directly related to the phenomenology of human experiences.