Associations of low density lipoprotein particle composition with atherogenicity
Associations of low density lipoprotein particle composition with atherogenicity
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DOI：
10.1097/00041433-200402000-00005
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发表时间：
2004-02-01
影响因子：
4.4
通讯作者：
Rudel, LL
中科院分区：
文献类型：
--
作者：
Lada, AT;Rudel, LL
越来越多的数据表明，除了LDL-胆固醇浓度外，LDL的组成特性，包括大小和脂肪酸组成，在决定动脉粥样硬化的相对程度方面也很重要。本文回顾了目前在这一领域的研究，以评估LDL的哪些特性可能最直接地影响冠心病的风险。最近的发现小密度低密度脂蛋白的存在与冠心病的风险增加有关，但这并没有完全独立于相关因素，如血浆甘油三酯浓度升高。小密度低密度脂蛋白对体外氧化的易感性增加也已被证实，但其对冠心病风险的重要性尚未确定。其他研究发现，LDL增大、LDL的修饰（油酸富集）脂肪酰基组成以及血浆中LDL颗粒数量增加也是与冠心病风险增加相关的终点。LDL大小可能表明与冠心病风险增加相关的代谢状况，而不是特定颗粒类型的LDL直接促进动脉粥样硬化。在大多数关于小密度LDL有害影响的声明中，LDL颗粒浓度和颗粒的脂肪酸组成都没有确定，这两个因素都是LDL致动脉粥样硬化潜力的重要因素。目前尚不能客观地将早发冠心病的易感性归因于任何一种LDL颗粒。
Purpose of reviewA growing body of data suggests that in addition to LDL-cholesterol concentrations, compositional properties of LDL, including size and fatty acid composition, are important in determining the relative degree of atherogenicity. This review examines current research in this field to evaluate which properties of LDL may most directly influence the risk of coronary heart disease.Recent findingsThe presence of small dense LDL has been correlated with an increased risk of coronary heart disease, but this has not been shown to be fully independent of related factors such as elevated plasma triacylglycerol concentrations. An increased susceptibility of small dense LDL to in-vitro oxidation has also been demonstrated, but its importance to coronary heart disease risk has not been established. Other studies have found that the presence of enlarged LDL, modified (oleate enriched) fatty acyl composition of LDL, and higher numbers of LDL particles in plasma also are endpoints associated with an increased risk of coronary heart disease.SummaryLDL size may indicate a metabolic condition associated with increased CHID risk as opposed to the direct promotion of atherosclerosis by specific particle types of LDL. In most claims of detrimental effects of small dense LDL, neither LDL particle concentrations nor the fatty acid composition of the particles were established, both factors being important in contributing to the atherogenic potential of LDL. The predisposition to premature coronary heart disease cannot currently be objectively assigned to any one type of LDL particle.