RHYTHMS IN BEHAVIORS, BODY-TEMPERATURE AND PLASMA-CORTICOSTERONE IN SCN LESIONED RATS GIVEN METHAMPHETAMINE
RHYTHMS IN BEHAVIORS, BODY-TEMPERATURE AND PLASMA-CORTICOSTERONE IN SCN LESIONED RATS GIVEN METHAMPHETAMINE
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DOI：
10.1016/0031-9384(88)90146-1
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发表时间：
1988-01-01
影响因子：
2.9
通讯作者：
HIROSHIGE, T
中科院分区：
文献类型：
--
作者：
HONMA, S;HONMA, K;HIROSHIGE, T
在非周期性大鼠与病变的视交叉上核（SCN），节奏与昼夜周期的自发运动轮运行，喂养，饮水，体温和血浆皮质酮恢复慢性给药的甲基苯丙胺。这些节奏并不受明暗循环的影响。大鼠的跑轮、摄食和饮水节律在超昼夜节律和昼夜节律波动方面是同步的。腹腔温度的节律性与自发运动节律性相伴随。这两种节律之间的相位关系与SCN依赖性节律相似。血浆皮质酮也以昼夜节律的方式波动。皮质酮峰值先于运动节律的活动开始数小时，这与SCN完整动物中观察到的相位关系相似。它的结论是，振荡机制的自发运动的节奏在SCN损伤和甲基苯丙胺治疗的大鼠驱动器也有其他的生理节奏。它们之间的相位关系类似于SCN中昼夜节律起搏器驱动的节律。
In aperiodic rats with lesions in the suprachiasmatic nuclei (SCN), rhythms with a circadian period in spontaneous locomotion wheel-running, feeding, drinking, body temperature and plasma corticosterone were restored by chronic administration of methamphetamine. The rhythms were not entrained by a light-dark cycle. Wheel-running, feeding and drinking rhythms in individual rats were in phase in terms of ultradian bout as well as circadian fluctuation. Rhythms of the intraperitoneal temperature appeared accompanying the spontaneous locomotor rhythm. The phase relation between the two rhythms was similar to that of SCN dependent rhythms. Plasma corticosterone also fluctuated in a circadian fashion. The corticosterone peak preceded the activity onset of locomotor rhythm by a few hours, which was similar to the phase relation observed in the SCN intact animals. It is concluded that the oscillatory mechanism underlying the spontaneous locomotor rhythm in SCN lesioned and methamphetamine treated rats drives also other physiological rhythms. The phase-relations among them were similar to those of rhythms driven by the circadian pacemaker in the SCN.