Linking the Rb and polycomb pathways
Linking the Rb and polycomb pathways
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DOI：
10.1016/s1097-2765(01)00346-x
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发表时间：
2001-09-01
期刊：
影响因子：
16
通讯作者：
Dean, DC
中科院分区：
文献类型：
--
作者：
Dahiya, A;Wong, S;Dean, DC
Polycomb group (PcG) proteins associate to form complexes that repress Hox genes, thereby imposing the patterning of Hox expression required for development. However, these proteins have a second Hox-independent role in regulating cell proliferation. Our results suggest that association between Rb and PcG proteins forms a repressor complex that blocks entry of cells into mitosis. Also, we provide evidence that Rb colocalizes with nuclear PcG complexes and is important for association of PcG complexes with nuclear targets. The Rb-PcG complex may provide a means to link cell cycle arrest to differentiation events leading to embryonic pattern formation.
