The factor VII activating protease G511E (Marburg) variant and cardiovascular risk
The factor VII activating protease G511E (Marburg) variant and cardiovascular risk
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DOI：
10.1160/th04-05-0275
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发表时间：
2004-11-01
影响因子：
6.7
通讯作者：
Humphries, SE
中科院分区：
文献类型：
--
作者：
Ireland, H;Miller, GJ;Humphries, SE
先前的一项研究表明，因子VII激活蛋白酶（FSAP G511E）的变异与晚期颈动脉粥样硬化之间存在密切关系。在体外，该变异具有降低的纤溶性，但正常的促凝活性，这可能构成血栓前状态。目前的研究在心血管疾病的前瞻性研究中解决了冠心病的风险（Northwick Park心脏研究II）。研究发现，511E等位基因与胆固醇和甘油三酯水平升高之间存在相互作用。纤维蛋白原可以代替甘油三酯水平进行风险相互作用分析。这些发现支持了FSAP511E等位基因加剧动脉粥样硬化或其临床后遗症的建议。
A previous study had shown a strong relationship between a variant in factor VII activating protease (FSAP G511E) and advanced carotid atheroma. In-vitro, the variant has reduced fibrinolytic but normal pro-coagulant activity, which may constitute a prothrombotic state. The current study has addressed risk for coronary heart disease in a prospective study of cardiovascular disorders (Northwick Park Heart Study II). An interactive effect upon risk was found between the 511E allele and elevated levels of cholesterol and triglyceride. Fibrinogen could substitute for triglyceride levels in this risk-interaction analysis. The findings support the proposal that the FSAP511E allele exacerbates atherosclerosis or its clinical sequelae.