Viral infections in short-term injection drug users: The prevalence of the hepatitis C, hepatitis B, human immunodeficiency, and human T-lymphotropic viruses
Viral infections in short-term injection drug users: The prevalence of the hepatitis C, hepatitis B, human immunodeficiency, and human T-lymphotropic viruses
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DOI：
10.2105/ajph.86.5.655
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发表时间：
1996-05-01
影响因子：
12.7
通讯作者：
Nelson, KE
中科院分区：
文献类型：
--
作者：
Garfein, RS;Vlahov, D;Nelson, KE
目标。本研究的目的是估计四种血源性病毒感染在有6年注射经验的非法药物注射者中的流行程度及其相关性。我们分析了1988年和1989年招募的716名志愿者的数据。丙型肝炎病毒（HCV）、乙型肝炎病毒（HBV）、人类免疫缺陷病毒、1型（HIV）和人类t淋巴细胞嗜性病毒I型和II型（HTLV）的检测结果在6个按药物注射时间定义的顺序队列中进行了检查。总体而言，HCV、HBV、HIV和HTLV的血清阳性率分别为76.9%、65.7%、20.5%和1.8%，注射1年及以下人群的血清阳性率分别为64.7%、49.8%、13.9%和0.5%；在新发病例中，HCV和HBV与注射变量相关，HIV与性变量相关。短期注射者中丙型肝炎病毒、乙型肝炎病毒和艾滋病毒感染率很高，这强调了需要及早采取肠道外和性风险降低干预措施。报告指出，应重新努力初级预防药物滥用。
Objectives. The purpose of this study was to estimate the prevalence and correlates of four blood-borne viral infections among illicit drug injectors with up to 6 years of injecting experience.Methods. We analyzed data from 716 volunteers recruited in 1988 and 1989. Test results for hepatitis C virus (HCV), hepatitis B virus (HBV), human immunodeficiency virus, type 1 (HIV), and human T-lymphotropic virus types I and II (HTLV) were examined across six sequential cohorts defined by duration of drug injection.Results. Overall, seroprevalence of HCV, HBV, HIV, and HTLV was 76.9%, 65.7%, 20.5% and 1.8%, respectively, and 64.7%, 49.8%, 13.9%, and 0.5%, respectively, among those who had injected for 1 year or less; Among the newest initiates, HCV and HBV were associated with injecting variables, and HIV was associated with sexual variables.Conclusions. The high rates of HCV, HBV, and HIV infections among short-term injectors emphasizes the need to target both parenteral and sexual risk reduction interventions early. Renewed efforts at primary prevention of substance abuse are indicated.