Tardive dyskinesia is not associated with the polymorphisms of 5-HT2A receptor gene, serotonin transporter gene and catechol-o-methyltransferase gene.
Tardive dyskinesia is not associated with the polymorphisms of 5-HT2A receptor gene, serotonin transporter gene and catechol-o-methyltransferase gene.
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迟发性运动障碍与5-HT2A受体基因、5-羟色胺转运蛋白基因、儿茶酚邻位甲基转移酶基因多态性无关。
DOI：
10.1016/s0924-9338(03)00005-1
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
H. Savaş
中科院分区：
文献类型：
--
作者：
H. Herken;M. Erdal;Ömer Böke;H. Savaş
目的探讨迟发性运动障碍（TD）与5-HT 2A受体基因、5-羟色胺转运体基因（5-HTT）和儿茶酚-O-甲基转移酶（COMT）基因多态性的关系。所有受试者都是土耳其裔。结果精神分裂症组、TD组和对照组的5-HT2A受体基因、5-HTT基因和COMT基因多态性差异无显著性。结论精神分裂症合并TD组、精神分裂症合并非TD组、TD组和对照组的5-HT2A受体基因、5-HTT基因和COMT基因多态性差异无显著性。健康的对照。然而，这些多态性无助于评估TD的易感性。
BackgroundThe pathophysiology of tardive dyskinesia (TD) is not completely understood.AimTo assess the relationship of TD with 5-HT2A receptor gene, serotonin transporter gene (5 HTT), and catechol-o-methyltransferase (COMT) gene polymorphisms.MethodsOur study comprised 111 unrelated subjects who strictly met DSM-IV criteria for schizophrenia and 32 TD, and 79 healthy unrelated controls; all the subjects were of Turkish origin. The analyses of 5-HT2A receptor gene, 5 HTT gene, and COMT gene polymorphisms were performed using polymerase chain reaction (PCR) technique.ResultsThe polymorphisms of these genes were not significantly different between the schizophrenic patients, TD and control subjects.ConclusionsOur findings indicated that 5-HT2A receptor gene, 5 HTT gene, and COMT gene polymorphisms were similar in schizophrenia with non-TD, schizophrenia with TD, and healthy controls. These polymorphisms, though, do not help to evaluate the susceptibility to TD.
与迟发性运动障碍相关的谷氨酸能神经传递和氧化应激的标志物。
DOI：
10.1176/ajp.155.9.1207
发表时间：
1998
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Tsai,G;Goff,DC;Chang,RW;Flood,J;Baer,L;Coyle,JT
通讯作者：
Coyle,JT
抗精神病药引起大鼠口腔运动障碍的机制。
DOI：
--
发表时间：
1993
期刊：
Polish journal of pharmacology
影响因子：
--
作者：
Rosengarten,H;Schweitzer,JW;Friedhoff,AJ
通讯作者：
Friedhoff,AJ