Viscoelasticity and shear wave velocity of liver tissue evaluated by dynamic mechanical analysis
Viscoelasticity and shear wave velocity of liver tissue evaluated by dynamic mechanical analysis
复制标题
通过动态力学分析评估肝组织的粘弹性和剪切波速度
DOI：
10.1109/ultsym.2015.0289
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
T. Yamaguchi
中科院分区：
文献类型：
--
作者：
K. Murakami;M. Tsukune;Y. Kobayashi;M. Fujie;R. Kishimoto;T. Obata;K. Kawamura;K. Yoshida;T. Yamaguchi
剪切波速的频率依赖性为评价肝纤维化相关组织的粘弹性特性提供了重要信息。虽然Voigt模型经常用于粘弹性分析，但一些研究表明，动态力学分析(DMA)试验测得的频率相关性与理论预测不一致。为了从实验上探讨组织结构变化与组织粘弹性的关系，采用剪切波弹性成像(SWE)和动态链接法(DMA)定量测定了大鼠脂肪肝和肝纤维化模型肝组织的剪切波速。在DMA试验中，剪切波速由复弹性模数、储能弹性模数和损耗弹性模数计算。脂肪肝与肝纤维化的剪切波速之差，SWE为0.27m/S，DMA为0.20m/S。
The frequency dependence of shear wave velocity provides significant information for evaluating viscoelastic character of tissue relating to liver fibrosis. Although Voigt model has been often used in viscoelastic analysis, several studies showed that the frequency dependence measured by dynamic mechanical analysis (DMA) test was not consistent with the theoretical prediction. To experimentally investigate the relationships of the change of the tissue structure and the viscoelasticity of tissue, the shear wave velocity of fatty and fibrotic livers of rat model was quantitatively measured by using shear wave elastography (SWE) and DMA test. In DMA test, shear wave velocity was calculated from the complex elasticity modulus; storage and loss elastic modulus. The difference in shear wave velocity between fatty and fibrotic livers was evaluated to be 0.27 m/s in SWE and 0.20 m/s in DMA test.