Immunometabolites Drive Bacterial Adaptation to the Airway.
Immunometabolites Drive Bacterial Adaptation to the Airway.
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DOI：
10.3389/fimmu.2021.790574
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发表时间：
2021
影响因子：
7.3
通讯作者：
Wong Fok Lung T
中科院分区：
文献类型：
--
作者：
Tomlinson KL;Prince AS;Wong Fok Lung T
铜绿假单胞菌和金黄色葡萄球菌都是经常与慢性肺部感染相关的机会致病菌。虽然细菌毒力决定因素在启动感染中至关重要，但这些细菌的代谢灵活性促进了它们在气道中的持久性。感染后，这些病原体诱导宿主免疫代谢重编程，导致气道环境充满免疫信号代谢物。这些代谢物通常对细菌有毒，并为适应在发炎肺中长期存活的细菌分离株的出现创造了陡峭的选择压力。在这篇综述中，我们讨论了宿主对铜绿假单胞菌和沙门氏菌免疫代谢反应的主要差异。金黄色葡萄球菌，以及这些病原体如何改变自己的代谢，以适应气道代谢产物，并导致持续性肺部感染。
Pseudomonas aeruginosa and Staphylococcus aureus are both opportunistic pathogens that are frequently associated with chronic lung infections. While bacterial virulence determinants are critical in initiating infection, the metabolic flexibility of these bacteria promotes their persistence in the airway. Upon infection, these pathogens induce host immunometabolic reprogramming, resulting in an airway milieu replete with immune-signaling metabolites. These metabolites are often toxic to the bacteria and create a steep selection pressure for the emergence of bacterial isolates adapted for long-term survival in the inflamed lung. In this review, we discuss the main differences in the host immunometabolic response to P. aeruginosa and S. aureus, as well as how these pathogens alter their own metabolism to adapt to airway metabolites and cause persistent lung infections.