Urban outbreak of acute Chagas disease in Amazon region of Brazil: four-year follow-up after treatment with benznidazole
Urban outbreak of acute Chagas disease in Amazon region of Brazil: four-year follow-up after treatment with benznidazole
复制标题
DOI：
10.1590/s1020-49892009000100012
复制
发表时间：
2009-01-01
期刊：
影响因子：
--
通讯作者：
Valente, Sebastião Aldo da Silva
中科院分区：
文献类型：
--
作者：
Pinto, Ana Yecê das Neves;Ferreira Jr., Alberto Gomes;Valente, Sebastião Aldo da Silva
本报告的目的是描述巴西亚马逊地区急性恰加斯病患者四年来的治疗结果。 2000 年 9 月，贝伦市区低收入地区爆发恰加斯病，同时影响 11 人，表明克氏锥虫有可能通过口腔间接传播。治疗前，患者接受身体和临床测试；血液样本经过免疫荧光测定（IFA）和定量血沉棕黄层（QBC）处理。用苯并硝唑治疗后，在四年内定期进行寄生虫学和血清学检测（克氏锥虫的人工异种诊断和血培养）、心电图和超声心动图。急性恰加斯病治疗四年后，所有患者的寄生虫学检测均呈阴性，且 IgG 抗 T 抗体持续存在。滴度降低的 cruzi 抗体；三名患者出现心电图异常，与慢性恰加斯病或急性疾病的后遗症一致。讨论了急性恰加斯病患者对治疗的满意反应和连续寄生虫学检查的相关性。
The objective of this report is to describe treatment outcomes over a four-year period of patients with acute Chagas disease in the Amazon region of Brazil. An outbreak of Chagas disease in a low-income district of urban Belem, in September 2000, affected 11 people simultaneously, indicating the likelihood of indirect, oral transmission of Trypanosoma cruzi. Prior to treatment, patients underwent physical and clinical tests; blood samples were processed with immunofluorescence assay (IFA) and quantitative buffy coat (QBC). Following treatment with benznidazole, parasitological and serologic tests (artificial xenodiagnosis and blood culture for T. cruzi), electrocardiogram, and echocardiogram were administered at intervals over a four-year period. Four years after treatment for acute Chagas disease, all patients presented with negative parasitological tests and persistent IgG anti-T. cruzi antibodies with lowered titers; three patients presented electrocardiogram abnormalities consistent with chronic Chagas disease or sequel of acute disease. The satisfactory response to treatment and relevance of serial parasitological examinations of patients with acute Chagas disease are discussed.