Evaluation of protection in grazing lambs immunised with different doses of Haemonchus conforms gut membrane glycoproteins in Southern Brazil
Evaluation of protection in grazing lambs immunised with different doses of Haemonchus conforms gut membrane glycoproteins in Southern Brazil
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DOI：
10.1016/j.vetpar.2021.109360
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发表时间：
2021-01-29
影响因子：
2.6
通讯作者：
Moraes, Jose C. F.
中科院分区：
文献类型：
--
作者：
Benavides, Magda, V;Souza, Carlos J. H.;Moraes, Jose C. F.
含有2 μ g至50 μ g来自捻转血矛线虫肠细胞的完整膜蛋白（H11和H-gal-GP复合物）的剂量范围的疫苗已显示对羔羊有效。H.在巴西南里奥格兰德的巴格郊区进行的为期8个月的试验中，在两个月大的放牧Corriedale羔羊中测试了捻转羊。将动物饲养在单个围场中，并根据体重、性别和粪便虫卵计数（FEC）将其分配至5个相似组。接种的羔羊接受0、2、5、10或50 μ g在基拉佐剂中稀释的相同抗原。在第0、21、49、91、133和175天进行疫苗注射。每周对羔羊进行FEC、红细胞压积（PCV）和血浆ELISA抗体滴度采样。接种PCV的羔羊
A vaccine containing doses ranging from 2 mu g to 50 mu g of integral membrane proteins from Haemonchus contortus intestinal cells (H11 and H-gal-GP complex) has been shown to be effective for lambs. A vaccine for H. contortus was tested in two-month old grazing Corriedale lambs during an eight-month trial on the outskirts of Bage, Rio Grande do Sul, Brazil. The animals were kept in a single paddock and allocated to five similar groups according to weight, sex and faecal egg counts (FEC). Vaccinated lambs received 0, 2, 5, 10 or 50 mu g of the same antigen diluted in QuilA adjuvant. Vaccine injections were given at days 0, 21, 49, 91, 133, and 175. Lambs were sampled weekly for FEC, packed cell volume (PCV), and plasma ELISA antibody titre. Lambs with PCVs