CONDITIONING AND EXTINCTION OF A FOOD-REWARDED RESPONSE AFTER SELECTIVE ABLATIONS OF FRONTAL CORTEX IN RHESUS MONKEYS
CONDITIONING AND EXTINCTION OF A FOOD-REWARDED RESPONSE AFTER SELECTIVE ABLATIONS OF FRONTAL CORTEX IN RHESUS MONKEYS
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DOI：
10.1016/0014-4886(63)90094-3
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发表时间：
1963-01-01
影响因子：
5.3
通讯作者：
ROSVOLD, HE
中科院分区：
文献类型：
--
作者：
BUTTER, CM;MISHKIN, M;ROSVOLD, HE
四只猴子眼眶额叶病变，四个侧额叶病变，和四个未手术的控制，所有这些都已训练术前按下一个杠杆的食物奖励，进行了测试，在空调会议交替灭绝会议。一个月后，在食物剥夺和饱食的条件下进行类似的条件反射和消退测试。与其他两组相比，眶额动物在灭绝中给出了更多的反应，并在条件反射中表现出较小的反应衰减时，从剥夺到饱足。这些发现支持了早期研究中提出的观点，即眶额猴在刺激分化测试中的损伤是由于难以抑制对阴性试验的反应。虽然先前的研究表明侧额叶猴子也有类似的损伤，但本实验中使用的程序未能检测到它。
Four monkeys with orbital frontal lesions, four with lateral frontal lesions, and four unoperated controls, all of which had been trained preoperatively to press a lever for food reward, were tested in conditioning sessions alternating with extinction sessions. One month later, similar conditioning and extinction tests were carried out under conditions of food deprivation and satiation. Compared to either of the other two groups, the orbital frontal animals gave more responses in extinction and showed a smaller response decrement in conditioning sessions when shifted from deprivation to satiation. These findings support the view advanced in an earlier study that the orbital frontal monkey''s impairment on stimulus differentiation tests is due to a difficulty in withholding responses on negative trials. Although previous studies suggest a similar impairment in lateral frontal monkeys, the procedures used in the present experiment failed to detect it.